ArticleClinical and experimental immunology2012
Functionality of CD4+ and CD8+ T cells from tonsillar tissue.
Article in Clinical and experimental immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Engineering human immune organoids for translational immunology.Bioactive materials · 2025Review
- Translational Frontiers and Clinical Opportunities of Immunologically Fitted Radiotherapy.Clinical cancer research : an official journal of the American Association for Cancer Research · 2024Review
- Review
- Innate adaptive immune cell dynamics in tonsillar tissues during chronic SIV infection.Frontiers in immunology · 2023Article
- Age-related changes of the innate immune system of the palatine tonsil in a healthy cohort.Frontiers in immunology · 2023Article
- Factors Limiting the Translatability of Rodent Model-Based Intranasal Vaccine Research to Humans.AAPS PharmSciTech · 2022Review
- Infection with SARS-CoV-2 primes immunological memory in human nasal-associated lymphoid tissue.Clinical immunology (Orlando, Fla.) · 2021Article
- Reconstructing Soma-Soma Synapse-like Vesicular Exocytosis with DNA Origami.ACS central science · 2021Article
- Article
- Highly Multiplexed Immunohistochemical MALDI-MS Imaging of Biomarkers in Tissues.Journal of the American Society for Mass Spectrometry · 2021Article
- The Whole Body as the System in Systems Immunology.iScience · 2020Review
- Silent Infection of B and CD8Journal of virology · 2020Article
- Article
- Tonsil-derived stem cells as a new source of adult stem cells.World journal of stem cells · 2019Review
- Immune responses after live attenuated influenza vaccination.Human vaccines & immunotherapeutics · 2018Review
- Nasal-associated lymphoid tissues (NALTs) support the recall but not priming of influenza virus-specific cytotoxic T cells.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Functional characterization of T-cells from palatine tonsils in patients with chronic tonsillitis.PloS one · 2017Article
- Accumulation of CD5Clinical and experimental medicine · 2016Article
- Live Attenuated Influenza Vaccine in Children Induces B-Cell Responses in Tonsils.The Journal of infectious diseases · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For many years, tonsillectomy has been used routinely in children to treat chronic or recurrent acute tonsillitis. Palatine tonsils are secondary lymphoid organs and the major barrier protecting the digestive and respiratory tracts from potential invasive microorganisms. They have been used as sources of lymphoid tissue; however, despite the hundreds of papers published on tonsillectomy, no studies addressing the functionality of the CD4(+) and CD8(+) T cells from chronically infected tonsils have yet been published. The aim of this study was to analyse the functionality of the CD4(+) and CD8(+) T cells with respect to tonsillar tissue. We used an affordable approach to measure the frequency of antigen-specific CD4(+) T cells, the direct ex-vivo cytotoxicity of CD8(+) T cells, memory T cell phenotype, cytokine profile and DC phenotype. Our results demonstrate that CD4(+) and CD8(+) T cells from tonsillar tissue are totally functional, as shown by their ability to produce cytokines, to degranulate and to differentiate into effector-memory T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.