ArticleWorld journal of orthopedics2012
Innervation of cervical ventral facet joint capsule: Histological evidence.
Article in World journal of orthopedics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Cervical facet capsular ligament mechanics: Estimations based on subject-specific anatomy and kinematics.JOR spine · 2023Article
- The innervation of the cervical facet joints-an anatomical and histological approach.Clinical anatomy (New York, N.Y.) · 2022Article
- Intra-articular MMP-1 in the spinal facet joint induces sustained pain and neuronal dysregulation in the DRG and spinal cord, and alters ligament kinematics under tensile loading.Frontiers in bioengineering and biotechnology · 2022Article
- Local tissue heterogeneity may modulate neuronal responses via altered axon strain fields: insights about innervated joint capsules from a computational model.Biomechanics and modeling in mechanobiology · 2021Article
- Peripheral and Central Pathological Mechanisms of Chronic Low Back Pain: A Narrative Review.Journal of pain research · 2021Review
- Intra-articular collagenase in the spinal facet joint induces pain, DRG neuron dysregulation and increased MMP-1 absent evidence of joint destruction.Scientific reports · 2020Article
- Overlapping, Masquerading, and Causative Cervical Spine and Shoulder Pathology: A Systematic Review.Global spine journal · 2020Review
- Article
- Collagen organization regulates stretch-initiated pain-related neuronal signals in vitro: Implications for structure-function relationships in innervated ligaments.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Multiscale mechanics of the cervical facet capsular ligament, with particular emphasis on anomalous fiber realignment prior to tissue failure.Biomechanics and modeling in mechanobiology · 2018Article
- A Nociceptive Role for Integrin Signaling in Pain After Mechanical Injury to the Spinal Facet Capsular Ligament.Annals of biomedical engineering · 2017Article
- Tissue loading and microstructure regulate the deformation of embedded nerve fibres: predictions from single-scale and multiscale simulations.Journal of the Royal Society, Interface · 2017Article
- Collagen Organization in Facet Capsular Ligaments Varies With Spinal Region and With Ligament Deformation.Journal of biomechanical engineering · 2017Article
- The Interface of Mechanics and Nociception in Joint Pathophysiology: Insights From the Facet and Temporomandibular Joints.Journal of biomechanical engineering · 2017Review
- Planar biaxial extension of the lumbar facet capsular ligament reveals significant in-plane shear forces.Journal of the mechanical behavior of biomedical materials · 2017Article
- Computer simulation of lumbar flexion shows shear of the facet capsular ligament.The spine journal : official journal of the North American Spine Society · 2017Article
- Tissue Strain Reorganizes Collagen With a Switchlike Response That Regulates Neuronal Extracellular Signal-Regulated Kinase Phosphorylation In Vitro: Implications for Ligamentous Injury and Mechanotransduction.Journal of biomechanical engineering · 2016Article
- Stretch-induced network reconfiguration of collagen fibres in the human facet capsular ligament.Journal of the Royal Society, Interface · 2016Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
aimTo assess the presence of nerves in ventral facet joint capsules as facet capsules are generally implicated in neck pain.
methodsTwenty-four ventral cervical facet joint capsules were harvested from 3 unembalmed cadavers. Paraffin sections from these capsules were processed to identify neurofilament and substance P immunoreactive fibers. Nerve fiber presence was also verified by a silver impregnation method.
resultsNeurofilament reactive fibers were observed in sections from 9 capsules. They were observed in areas with collagen fibers and areas with irregular connective tissue. Substance P reactive nerve fibers were found in sections from 7 capsules in similar areas. Silver impregnation also revealed the presence of nerve fibers. The nerve fibers were also found as bundles in the lateral margins of the capsule. A Pacinian corpuscle-like ending was also observed in one specimen.
conclusionNerve fibers revealed by neurofilament immunoreactivity and silver staining support innervation of the ventral aspect of the facet joint capsule. The presence of substance P reactive fibers supports the potential role of these elements in mediating pain. The presence of a Pacinian-like ending implicates a potential role in joint movement.
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Registered trials
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