ReviewViruses2012
Back to BAC: the use of infectious clone technologies for viral mutagenesis.
Review in Viruses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- The Quest for Immunity: Exploring Human Herpesviruses as Vaccine Vectors.International journal of molecular sciences · 2023Review
- Construction of a Novel Infectious Clone of Recombinant Herpesvirus of Turkey Fc-126 Expressing VP2 of IBDV.Vaccines · 2022Article
- Methods for the Manipulation of Herpesvirus Genome and the Application to Marek's Disease Virus Research.Microorganisms · 2021Review
- In vitro and in vivo characterization of a recombinant rhesus cytomegalovirus containing a complete genome.PLoS pathogens · 2020Article
- Article
- miRNA-mediated targeting of human cytomegalovirus reveals biological host and viral targets of IE2.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Genome-wide engineering of an infectious clone of herpes simplex virus type 1 using synthetic genomics assembly methods.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Construction of Gpm6a/ReelinWorld journal of gastroenterology · 2017Article
- λ Recombination and Recombineering.EcoSal Plus · 2016Review
- Article
- Genomic deletions and mutations resulting in the loss of eight genes reduce the in vivo replication capacity of Meleagrid herpesvirus 1.Virus genes · 2015Article
- A modified screening system for loss-of-function and dominant negative alleles of essential MCMV genes.PloS one · 2014Article
- Nuclear export of VP19C is not essential for replication of herpes simplex virus type 1.Cell & bioscience · 2014Article
- A simplified positive-sense-RNA virus construction approach that enhances analysis throughput.Journal of virology · 2013Article
- Efficient generation of recombinant RNA viruses using targeted recombination-mediated mutagenesis of bacterial artificial chromosomes containing full-length cDNA.BMC genomics · 2013Article
- A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis.Virology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial artificial chromosome (BAC) vectors were first developed to facilitate the propagation and manipulation of large DNA fragments in molecular biology studies for uses such as genome sequencing projects and genetic disease models. To facilitate these studies, methodologies have been developed to introduce specific mutations that can be directly applied to the mutagenesis of infectious clones (icBAC) using BAC technologies. This has resulted in rapid identification of gene function and expression at unprecedented rates. Here we review the major developments in BAC mutagenesis in vitro. This review summarises the technologies used to construct and introduce mutations into herpesvirus icBAC. It also explores developing technologies likely to provide the next leap in understanding these important viruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.