ArticleMolecular and cellular biology1990
Sequence and functional similarity between a yeast ribosomal protein and the Escherichia coli S5 ram protein.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Phenotype of Mrps5-Associated Phylogenetic Polymorphisms Is Intimately Linked to Mitoribosomal Misreading.International journal of molecular sciences · 2022Article
- Engineering and functional analysis of yeast with a monotypic 40S ribosome subunit.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The control of translational accuracy is a determinant of healthy ageing in yeast.Open biology · 2017Article
- Zfrp8/PDCD2 Interacts with RpS2 Connecting Ribosome Maturation and Gene-Specific Translation.PloS one · 2016Article
- Identification of photoperiod-regulated gene in soybean and functional analysis in Nicotiana benthamiana.Journal of genetics · 2014Article
- Review
- Nuclear export competence of pre-40S subunits in fission yeast requires the ribosomal protein Rps2.Nucleic acids research · 2008Article
- PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits.The EMBO journal · 2004Article
- Translational suppressors and antisuppressors alter the efficiency of the Ty1 programmed translational frameshift.RNA (New York, N.Y.) · 1999Article
- The 5' end of the 18S rRNA can be positioned from within the mature rRNA.RNA (New York, N.Y.) · 1999Article
- The duplicated Saccharomyces cerevisiae gene SSM1 encodes a eucaryotic homolog of the eubacterial and archaebacterial L1 ribosomal proteins.Molecular and cellular biology · 1995Article
- Translation elongation factor-3 (EF-3): an evolving eukaryotic ribosomal protein?Journal of molecular evolution · 1995Article
- NMR solution structure of a dsRNA binding domain from Drosophila staufen protein reveals homology to the N-terminal domain of ribosomal protein S5.The EMBO journal · 1995Article
- A genetic screen identifies cellular factors involved in retroviral -1 frameshifting.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- A mutant allele of the SUP45 (SAL4) gene of Saccharomyces cerevisiae shows temperature-dependent allosuppressor and omnipotent suppressor phenotypes.Current genetics · 1995Article
- The Cys-His motif of Ty3 NC can be contributed by Gag3 or Gag3-Pol3 polyproteins.Journal of virology · 1994Article
- A novel RNA-binding motif in omnipotent suppressors of translation termination, ribosomal proteins and a ribosome modification enzyme?Nucleic acids research · 1994Article
- Polypeptide chain termination in Saccharomyces cerevisiae.Current genetics · 1994Review
- An accuracy center in the ribosome conserved over 2 billion years.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- NAB2: a yeast nuclear polyadenylated RNA-binding protein essential for cell viability.Molecular and cellular biology · 1993Article
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Authors and funding
4 authors.
Funding
Abstract
The accurate and efficient translation of proteins is of fundamental importance to both bacteria and higher organisms. Most of our knowledge about the control of translational fidelity comes from studies of Escherichia coli. In particular, ram (ribosomal ambiguity) mutations in structural genes of E. coli ribosomal proteins S4 and S5 have been shown to increase translational error frequencies. We describe the first sequence of a ribosomal protein gene that affects translational ambiguity in a eucaryote. We show that the yeast omnipotent suppressor SUP44 encodes the yeast ribosomal protein S4. The gene exists as a single copy without an intron. The SUP44 protein is 26% identical (54% similar) to the well-characterized E. coli S5 ram protein. SUP44 is also 59% identical (78% similar) to mouse protein LLrep3, whose function was previously unknown (D.L. Heller, K.M. Gianda, and L. Leinwand, Mol. Cell. Biol. 8:2797-2803, 1988). The SUP44 suppressor mutation occurs near a region of the protein that corresponds to the known positions of alterations in E. coli S5 ram mutations. This is the first ribosomal protein whose function and sequence have been shown to be conserved between procaryotes and eucaryotes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.