ArticleMolecular and cellular biology1990
The SCL gene is formed from a transcriptionally complex locus.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 98 citations in OpenAlex.
- Transcription Factor TAL1 in Erythropoiesis.Advances in experimental medicine and biology · 2024Review
- Genomic Alterations of Non-Coding Regions Underlie Human Cancer: Lessons from T-ALL.Trends in molecular medicine · 2016Review
- Review
- Aberrant TAL1 activation is mediated by an interchromosomal interaction in human T-cell acute lymphoblastic leukemia.Leukemia · 2014Article
- Article
- Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus.PloS one · 2010Article
- Inhibition of all-trans retinoic acid-induced granulocytic differentiation of WEHI-3B D+ cells by forced expression of SCL (TAL1) and GATA-1.Leukemia research · 2009Article
- Review
- Distinct functions for different scl isoforms in zebrafish primitive and definitive hematopoiesis.PLoS biology · 2007Article
- Cre-loxP-mediated recombination between the SIL and SCL genes leads to a block in T-cell development at the CD4- CD8- to CD4+ CD8+ transition.Neoplasia (New York, N.Y.) · 2007Article
- Altered transcription of the stem cell leukemia gene in myelofibrosis with myeloid metaplasia.Leukemia · 2003Article
- Translational control of SCL-isoform expression in hematopoietic lineage choice.Genes & development · 2003Article
- Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.The EMBO journal · 2002Article
- Regulation of the stem cell leukemia (SCL) gene: a tale of two fishes.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice.Leukemia · 2001Article
- Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice.Molecular and cellular biology · 1999Article
- Sequence determinants of DNA binding by the hematopoietic helix-loop-helix transcription factor TAL1: importance of sequences flanking the E-box core.Gene expression · 1998Article
- DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis.Molecular and cellular biology · 1997Article
- An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice.The EMBO journal · 1997Article
- Nhlh1, a basic helix-loop-helix transcription factor, is very tightly linked to the mouse looptail (Lp) mutation.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe the structural organization of the human SCL gene, a helix-loop-helix family member which we believe plays a fundamental role in hematopoietic differentiation. The SCL locus is composed of eight exons distributed over 16 kb. SCL shows a pattern of expression quite restricted to early hematopoietic tissues, although in malignant states expression of the gene may be somewhat extended into later developmental stages. A detailed analysis of the transcript(s) arising from the SCL locus revealed that (i) the 5' noncoding portion of the SCL transcript, which resides within a CpG island, has a complex pattern of alternative exon utilization as well as two distinct transcription initiation sites; (ii) the 5' portions of the SCL transcript contain features that suggest a possible regulatory role for these segments; (iii) the pattern of utilization of the 5' exons is cell lineage dependent; and (iv) all of the currently studied chromosomal aberrations that affect the SCL locus either structurally or functionally eliminate the normal 5' transcription initiation sites. These data suggest that the SCL gene, and specifically its 5' region, may be a target for regulatory interactions during early hematopoietic development.
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