ArticlePloS one2012
Insect neuropeptide bursicon homodimers induce innate immune and stress genes during molting by activating the NF-κB transcription factor Relish.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 104 citations in OpenAlex.
- A Tale of Two States: Similarities and Differences in Neuropeptide Signaling in Larval and Adult Drosophila.The Journal of comparative neurology · 2026Review
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- Nymphal diets boost adults' immunity via strengthened constitutive immunity and metabolic capacity in Adelphocoris suturalis.Communications biology · 2025Article
- Inducing bursicon expression using 20-hydroxyecdysone (20E) increased immune response in Macrobrachium rosenbergii against Aeromonas hydrophila.Biology open · 2025Article
- Article
- Neuropeptide Bursicon and its receptor-mediated the transition from summer-form to winter-form ofeLife · 2024Article
- Cereal weevils' antimicrobial peptides: at the crosstalk between development, endosymbiosis and immune response.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Editorial: Neuropeptide actions in arthropod biology.Frontiers in endocrinology · 2024Article
- TGF-β Type II Receptor Punt Suppresses Antimicrobial Peptide Expression and Influences Development inInsects · 2023Article
- Review
- Neuropeptide hormone bursicon mediates female reproduction in the whitefly,Frontiers in endocrinology · 2023Article
- Identification and characterization of ecdysis-related neuropeptides in the lone star tickFrontiers in endocrinology · 2023Article
- The gut hormone Allatostatin C/Somatostatin regulates food intake and metabolic homeostasis under nutrient stress.Nature communications · 2022Article
- Early-Stage Defense Mechanism of the Cotton AphidFrontiers in immunology · 2022Article
- Article
- Identification and recombinant expression of an antimicrobial peptide (cecropin B-like) from soybean pestThe journal of venomous animals and toxins including tropical diseases · 2021Article
- Unconventional Actions of Glycoprotein Hormone Subunits: A Comprehensive Review.Frontiers in endocrinology · 2021Review
- Neuropeptide Bursicon Influences Reproductive Physiology inFrontiers in physiology · 2021Article
- Metabolism and growth adaptation to environmental conditions in Drosophila.Cellular and molecular life sciences : CMLS · 2020Review
- Hepatopancreas immune response during molt cycle in the mud crab, Scylla paramamosain.Scientific reports · 2020Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBursicon is a heterodimer neuropeptide composed of two cystine knot proteins, bursicon α (burs α) and bursicon β (burs β), that elicits cuticle tanning (melanization and sclerotization) through the Drosophila leucine-rich repeats-containing G protein-coupled receptor 2 (DLGR2). Recent studies show that both bursicon subunits also form homodimers. However, biological functions of the homodimers have remained unknown until now. METHODOLOGY/PRINCIPAL
findingsIn this report, we show in Drosophila melanogaster that both bursicon homodimers induced expression of genes encoding antimicrobial peptides (AMPs) in neck-ligated adults following recombinant homodimer injection and in larvae fat body after incubation with recombinant homodimers. These AMP genes were also up-regulated in 24 h old unligated flies (when the endogenous bursicon level is low) after injection of recombinant homodimers. Up-regulation of AMP genes by the homodimers was accompanied by reduced bacterial populations in fly assay preparations. The induction of AMP expression is via activation of the NF-κB transcription factor Relish in the immune deficiency (Imd) pathway. The influence of bursicon homodimers on immune function does not appear to act through the heterodimer receptor DLGR2, i.e. novel receptors exist for the homodimers. CONCLUSIONS/SIGNIFICANCE: Our results reveal a mechanism of CNS-regulated prophylactic innate immunity during molting via induced expression of genes encoding AMPs and genes of the Turandot family. Turandot genes are also up-regulated by a broader range of extreme insults. From these data we infer that CNS-generated bursicon homodimers mediate innate prophylactic immunity to both stress and infection during the vulnerable molting cycle.
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