ArticlePloS one2012
Microfluidic synthesis of microfibers for magnetic-responsive controlled drug release and cell culture.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 85 citations in OpenAlex.
- Microfluidic-assisted fiber production: Potentials, limitations, and prospects.Biomicrofluidics · 2022Review
- Recent Advances of Microfluidic Platforms for Controlled Drug Delivery in Nanomedicine.Drug design, development and therapy · 2021Review
- Facile synthesis of highly tunable monodispersed calcium hydroxide composite particles by using a two-step ion exchange reaction.RSC advances · 2020Article
- Microfluidic Synthesis of Vinblastine-Loaded Multifunctional Particles for Magnetically Responsive Controlled Drug Release.Pharmaceutics · 2019Article
- Microfluidic Spun Alginate Hydrogel Microfibers and Their Application in Tissue Engineering.Gels (Basel, Switzerland) · 2018Review
- 3D printed metal molds for hot embossing plastic microfluidic devices.Lab on a chip · 2017Article
- Can microfluidics address biomanufacturing challenges in drug/gene/cell therapies?Regenerative biomaterials · 2016Review
- Synthesis and anti-fungal effect of silver nanoparticles-chitosan composite particles.International journal of nanomedicine · 2015Article
- Synthesis and characterization of oil-chitosan composite spheres.Molecules (Basel, Switzerland) · 2013Article
- Dripping and jetting in microfluidic multiphase flows applied to particle and fiber synthesis.Journal of physics D: Applied physics · 2013Article
- Hybrid nanostructured coating for increased resistance of prosthetic devices to staphylococcal colonization.Nanoscale research letters · 2013Article
- Improved fibronectin-immobilized fibrinogen microthreads for the attachment and proliferation of fibroblasts.International journal of nanomedicine · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study demonstrated the fabrication of alginate microfibers using a modular microfluidic system for magnetic-responsive controlled drug release and cell culture. A novel two-dimensional fluid-focusing technique with multi-inlets and junctions was used to spatiotemporally control the continuous laminar flow of alginate solutions. The diameter of the manufactured microfibers, which ranged from 211 µm to 364 µm, could be well controlled by changing the flow rate of the continuous phase. While the model drug, diclofenac, was encapsulated into microfibers, the drug release profile exhibited the characteristic of a proper and steady release. Furthermore, the diclofenac release kinetics from the magnetic iron oxide-loaded microfibers could be controlled externally, allowing for a rapid drug release by applying a magnetic force. In addition, the successful culture of glioblastoma multiforme cells in the microfibers demonstrated a good structural integrity and environment to grow cells that could be applied in drug screening for targeting cancer cells. The proposed microfluidic system has the advantages of ease of fabrication, simplicity, and a fast and low-cost process that is capable of generating functional microfibers with the potential for biomedical applications, such as drug controlled release and cell culture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.