ArticleNephron extra2011
Serum high-sensitivity cardiac troponin T is a significant biomarker of left-ventricular diastolic dysfunction in subjects with non-diabetic chronic kidney disease.
Article in Nephron extra, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Pooled it
- Impaired renal function is a major determinant of left ventricular diastolic dysfunction: assessment by stress myocardial perfusion imaging.Annals of nuclear medicine · 2013Trial
- Cardiac Troponins in Kidney Disease.European cardiology · 2025Review
- The association between higher cardiac troponin levels and the development of left ventricular diastolic dysfunction in septic patients with diabetes mellitus.The international journal of cardiovascular imaging · 2024Article
- Value of troponin T as a screening test of cardiac structure and function in chronic kidney disease.Global cardiology science & practice · 2021Article
- Potential determinants of the E/e' ratio in non-dialysis compared with dialysis patients.Nephrology (Carlton, Vic.) · 2021Article
- Can Long-Distance Walking alter Cardiac Biomarkers and Echocardiographic Variables Related to Diastolic Function?Arquivos brasileiros de cardiologia · 2020Article
- Diastolic Function and Biomarkers of Long-Distance Walking Participants.Arquivos brasileiros de cardiologia · 2020Article
- Serum cystatin C is an independent biomarker associated with the renal resistive index in patients with chronic kidney disease.PloS one · 2018Article
- Urine Trefoil Factors as Prognostic Biomarkers in Chronic Kidney Disease.BioMed research international · 2018Article
- Utility of traditional circulating and imaging-based cardiac biomarkers in patients with predialysis CKD.Clinical journal of the American Society of Nephrology : CJASN · 2015Review
- The Correlation between Serum Level of Leptin and Troponin in Children with Major Beta-Thalassemia.Iranian journal of pediatric hematology and oncology · 2015Article
- The Correlation between Troponin and Ferritin Serum Levels in the Patients with Major Beta-Thalassemia.International cardiovascular research journal · 2013Article
- Article
- Cardiorenal biomarkers in acute heart failure.Journal of geriatric cardiology : JGC · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic kidney disease (CKD) is associated with left-ventricular (LV) diastolic dysfunction (LVDD) which progresses to diastolic heart failure. However, biomarkers predicting LVDD in patients with CKD are largely unknown.
methodsIn 93 patients with non-diabetic CKD, the relationships among echocardiography, high-sensitivity cardiac troponin T (hs-cTnT), B-type natriuretic peptide (BNP), and renal function were evaluated. LV mass index, peak early diastolic mitral filling velocity (E), peak early diastolic mitral annular velocity (E'), and E/E' were recorded.
resultsThe E' values were significantly decreased and E/E', BNP, and hs-cTnT increased with increasing CKD stage. The CKD patients with LVDD with E' <5 cm/s had a significantly higher hs-cTnT level as well as a significantly higher BNP level compared to those with E' ≥5 cm/s. The area under the receiver-operating characteristic curve for hs-cTnT and BNP to detect E' <5 cm/s was 0.880 (p = 0.0101) and 0.741 (p = 0.0570), respectively. In multivariate analysis, hs-cTnT and albuminuria were significantly associated with E', and estimated glomerular filtration rate with the hs-cTnT level, after adjusting for age, cause of CKD, and other parameters.
conclusionsThese data suggest that hs-cTnT may be a useful biomarker of LVDD in non- diabetic CKD patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.