ArticleFrontiers in systems neuroscience2012
Novel chalcone-based fluorescent human histamine h(3) receptor ligands as pharmacological tools.
Article in Frontiers in systems neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 37 citations in OpenAlex.
- Naturally Occurring Chalcones with Aggregation-Induced Emission Enhancement Characteristics.Molecules (Basel, Switzerland) · 2023Article
- Two-Photon Absorption and Multiphoton Excited Fluorescence of Acetamide-Chalcone Derivatives: The Role of Dimethylamine Group on the Nonlinear Optical and Photophysical Properties.Molecules (Basel, Switzerland) · 2023Article
- Article
- Photophysical Study and Biological Applications of Synthetic Chalcone-Based Fluorescent Dyes.Molecules (Basel, Switzerland) · 2021Article
- Crystal structures of three functionalized chalcones: 4'-di-methyl-amino-3-nitro-chalcone, 3-di-methyl-amino-3'-nitrochalcone and 3'-nitro-chalcone.Acta crystallographica. Section E, Crystallographic communications · 2020Article
- Ultraspecific live imaging of the dynamics of zebrafish neutrophil granules by a histopermeable fluorogenic benzochalcone probe.Chemical science · 2019Article
- Chalcone: A Privileged Structure in Medicinal Chemistry.Chemical reviews · 2017Review
- Pharmacological Characterization of Human Histamine Receptors and Histamine Receptor Mutants in the Sf9 Cell Expression System.Handbook of experimental pharmacology · 2017Review
- The evolving small-molecule fluorescent-conjugate toolbox for Class A GPCRs.British journal of pharmacology · 2014Review
- Histamine in the brain.Frontiers in systems neuroscience · 2014Article
- Bodilisant-a novel fluorescent, highly affine histamine h3 receptor ligand.ACS medicinal chemistry letters · 2013Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Novel fluorescent chalcone-based ligands at human histamine H(3) receptors (hH(3)R) have been designed, synthesized, and characterized. Compounds described are non-imidazole analogs of ciproxifan with a tetralone motif. Tetralones as chemical precursors and related fluorescent chalcones exhibit affinities at hH(3)R in the same concentration range like the reference antagonist ciproxifan (hH(3)R pK(i) value of 7.2). Fluorescence characterization of our novel ligands shows emission maxima about 570 nm for yellow fluorescent chalcones and ≥600 nm for the red fluorescent derivatives. Interferences to cellular autofluorescence could be excluded. All synthesized chalcone compounds could be used to visualize hH(3)R proteins in stably transfected HEK-293 cells using confocal laser scanning fluorescence microscopy. These novel fluorescent ligands possess high potential to be used as pharmacological tools for hH(3)R visualization in different tissues.
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