Evidence map›Paper›PMID 22470299›Full record

SynthesisInternational journal of environmental research and public health2012

Physical activity and risk of cardiovascular disease--a meta-analysis of prospective cohort studies.

Jian Li, Johannes Siegrist

2 registry-linked trialsAbstract readMeta-AnalysisReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of environmental research and public health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 266 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
266citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02778165 naunknown statusnot on this mapstarted 2022, after this paper: background citation

My Cardiac Recovery (MyCaRe): A Pilot RCT to Examine the Effect of MyCaRe Android Application on Recovery Outcomes and Enrolment in Cardiac Rehab Post Cardiac Surgery.

TypeinterventionalSponsorUniversity Health Network, TorontoRan2022 to 2024Enrolled40ConditionsPostoperative, Dysfunction Following Cardiac SurgeryArmsMyCaRe (my cardiac recovery Android application)
NCT03869112 naunknown statusnot on this mapstarted 2019, after this paper: background citation

The Effectiveness of a Physical Activity Intervention Versus Pulmonary Rehabilitation on Cardiovascular Risk Markers for Individuals With Chronic Obstructive Pulmonary Disease: a Feasibility Study

TypeinterventionalSponsorUniversity Hospitals, LeicesterRan2019 to 2020Enrolled60ConditionsCardiovascular Diseases, Cardiovascular Risk Factor, COPDArmsPhysical activity intervention, Pulmonary rehabilitation group
3 · Its place in the literature

Who cites it

266 citing papers in PubMed, 15 syntheses or guidelines pooled it.

  1. Physical Activity, Cognitive Health and Learning in Youth: A Narrative Umbrella Review.International journal of environmental research and public health · 2025
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  7. Could Physical Activity Have any Role in Cardiovascular Disease Prevention in Prisoners? A Systematic Review.International journal of environmental research and public health · 2021
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  13. The 2017 Dutch Physical Activity Guidelines.The international journal of behavioral nutrition and physical activity · 2018
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206 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jian LiMannheim Institute of Public Health, Social and Preventive Medicine, Mannheim Medical Faculty, Heidelberg University, Ludolf-Krehl Strasse 7-11, 68167 Mannheim, Germany. lijian1974@hotmail.com
Johannes Siegrist

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to update and improve available evidence on associations of physical activity (PA) with cardiovascular disease (CVD) by applying meta-analytic random effects modeling to data from prospective cohort studies, using high quality criteria of study selection, we searched the PubMed database from January 1980 to December 2010 for prospective cohort studies of PA and incident CVD, distinguishing occupational PA and leisure time PA, coronary heart disease (CHD) and stroke, respectively. Inclusion criteria were peer-reviewed English papers with original data, studies with large sample size (n ≥ 1,000) and substantial follow-up (≥ 5 years), available data on major confounders and on estimates of relative risk (RR) or hazard ratio (HR), with 95% confidence intervals (CI). We included 21 prospective studies in the overall analysis, with a sample size of more than 650,000 adults who were initially free from CVD, and with some 20,000 incident cases documented during follow-up. Among men, RR of overall CVD in the group with the high level of leisure time PA was 0.76 (95% CI 0.70-0.82, p < 0.001), compared to the reference group with low leisure time PA, with obvious dose-response relationship. A similar effect was observed among women (RR = 0.73, 95% CI 0.68-0.78, p < 0.001). A strong protective effect of occupational PA was observed for moderate level in both men (RR = 0.89, 95% CI 0.82-0.97, p = 0.008) and women (RR = 0.83, 95% CI 0.67-1.03, p = 0.089). No publication bias was observed. Our findings suggest that high level of leisure time PA and moderate level of occupational PA have a beneficial effect on cardiovascular health by reducing the overall risk of incident coronary heart disease and stroke among men and women by 20 to 30 percent and 10 to 20 percent, respectively. This evidence from high quality studies supports efforts of primary and secondary prevention of CVD in economically advanced as well as in rapidly developing countries.

Indexed as

Motor ActivityCardiovascular DiseasesEvidence-Based MedicineFemaleHumansMaleProspective StudiesRisk Factorscardiovascular diseasecoronary heart diseaseepidemiological cohortmeta-analysisphysical activitystroke

Identifiers

PMID22470299
PMCPMC3315253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.