ReviewAdvances in neonatal care : official journal of the National Association of Neonatal Nurses2012
Necrotizing enterocolitis risk: state of the science.
Review in Advances in neonatal care : official journal of the National Association of Neonatal Nurses, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03631979 (Regular Intestinal Lavage to Promote Enteral Feeding and Prevent Necrotizing Enterocolitis in Extremely Preterm Infants. A Randomized Controlled Trial Protocol), which is not on this map. Cited by 122 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Regular Intestinal Lavage to Promote Enteral Feeding and Prevent Necrotizing Enterocolitis in Extremely Preterm Infants. A Randomized Controlled Trial Protocol
Who cites it
122 citing papers in PubMed, 4 syntheses or guidelines pooled it, 247 citations in OpenAlex.
- Optimal enteral feeding after surgery for necrotising enterocolitis: a systematic review.Pediatric surgery international · 2026Pooled it
- Bifidobacterium and Lactobacillus for preventing necrotizing enterocolitis in very-low-birth-weight preterm infants: a systematic review and meta-analysis.World journal of pediatrics : WJP · 2020Pooled it
- Human milk-derived fortifier versus bovine milk-derived fortifier for prevention of mortality and morbidity in preterm neonates.The Cochrane database of systematic reviews · 2019Pooled it
- Probiotics for prevention of necrotizing enterocolitis in preterm infants: systematic review and meta-analysis.Italian journal of pediatrics · 2015Pooled it
- Effect of Maternal Diet on Any Necrotizing Enterocolitis in Neonates: A Randomized Double-Blind Study.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2022Trial
- Financial Support to Medicaid-Eligible Mothers Increases Caregiving for Preterm Infants.Maternal and child health journal · 2020Trial
- The Infant Feeding History: An Evidence-Informed 9-Item Structured History for Detecting Serious Illness in the Emergency Department.Journal of the American College of Emergency Physicians open · 2026Article
- Defining growth faltering and malnutrition among very preterm infants in a neonatal intensive care unit.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- The central function and specific molecular mechanisms of the TLR4 pathway underlying impaired intestinal barrier in necrotizing enterocolitis.Biochemistry and biophysics reports · 2026Review
- Validation of a Predictive Nomogram for Mortality Among Neonates With Necrotizing Enterocolitis in Tertiary Care Hospitals at Bahir Dar City, Bahir Dar, Northwest Ethiopia.Clinical medicine insights. Pediatrics · 2026Article
- Mesenchymal stromal cell therapy restores intestinal integrity and attentuates inflammation in a preterm piglet model of necrotizing enterocolitis.Pediatric surgery international · 2026Article
- Transcriptional stratification of necrotizing enterocolitis identifies distinct disease subtypes.Scientific reports · 2026Article
- Preterm infant formulas with glucose polymers and reduced lactose content increase the risk of necrotizing enterocolitis.Frontiers in nutrition · 2026Review
- Necrotizing Enterocolitis in Preterm Infants: An Inflammatory Condition at the Crossroads of Intestinal Immaturity, Dysbiosis, and Nutrition.International journal of pediatrics · 2026Review
- Extensively hydrolyzed versus intact milk protein formula and risk of necrotizing enterocolitis: a meta-analysis.Frontiers in pediatrics · 2026Review
- Risk factors and prediction model for necrotizing enterocolitis in preterm infants with gestational age ≤ 32 weeks: a retrospective cohort study.Frontiers in pediatrics · 2026Article
- [Recent advances in artificial intelligence for auxiliary diagnosis and management of neonatal necrotizing enterocolitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025Review
- An early post-birth immune-microbiota landscape predicts the development of necrotizing enterocolitis in term newborns with congenital heart defects.Scientific reports · 2025Article
- Synergism between TLR4 and B. infantis in the development of the premature intestine.Pediatric research · 2025Article
- Impact of changing donor human milk feeding guideline for extremely preterm infants on the use of infant formula and cost of donor human milk purchase.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Necrotizing enterocolitis (NEC) is the most common cause of gastrointestinal-related morbidity and mortality in the neonatal intensive care unit (NICU). Its onset is sudden and the smallest, most premature infants are the most vulnerable. Necrotizing enterocolitis is a costly disease, accounting for nearly 20% of NICU costs annually. Necrotizing enterocolitis survivors requiring surgery often stay in the NICU more than 90 days and are among those most likely to stay more than 6 months. Significant variations exist in the incidence across regions and units. Although the only consistent independent predictors for NEC remain prematurity and formula feeding, others exist that could increase risk when combined. Awareness of NEC risk factors and adopting practices to reduce NEC risk, including human milk feeding, the use of feeding guidelines, and probiotics, have been shown to reduce the incidence of NEC. The purpose of this review is to examine the state of the science on NEC risk factors and make recommendations for practice and research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.