ArticleClinical and experimental hypertension (New York, N.Y. : 1993)2012
Epigenetics and microRNAs in preeclampsia.
Article in Clinical and experimental hypertension (New York, N.Y. : 1993), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- Unveiling preeclampsia: diagnostic value and potential molecular mechanisms of abnormally methylated immune-related genes.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026Article
- Environmental Toxicants in the Hispanic Community Epigenetically Contributing to Preeclampsia.Cardiovascular toxicology · 2025Review
- Hypertension as predictive factor for bevacizumab-containing first-line therapy in metastatic breast and colorectal cancer in BRECOL (GEICAM/2011-04) study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Observational
- High-throughput methylome analysis reveals differential methylation for early and late onset preeclampsia for mothers and their children.Physiological genomics · 2024Article
- Mono-(2-ethylhexyl) phthalate induces trophoblast hypoxia and mitochondrial dysfunction through HIF-1α-miR-210-3p axis in HTR-8/SVneo cell line.Current research in toxicology · 2024Article
- Exposure to endocrine disrupting chemicals impacts immunological and metabolic status of women during pregnancy.Molecular and cellular endocrinology · 2023Article
- Long-Term Consequences of Placental Vascular Pathology on the Maternal and Offspring Cardiovascular Systems.Biomolecules · 2021Review
- Association Between Preeclampsia Risk and Fine Air Pollutants and Acidic Gases: A Cohort Analysis in Taiwan.Frontiers in public health · 2021Article
- microRNA-646 inhibits angiogenesis of endothelial progenitor cells in pre-eclamptic pregnancy by targeting the VEGF-A/HIF-1α axis.Experimental and therapeutic medicine · 2020Article
- Differential Methylation in Promoter Regions of the GenesFrontiers in medicine · 2020Article
- The effect of miR-146a rs2910164 and miR-149 rs2292832 polymorphisms on preeclampsia susceptibility.Molecular biology reports · 2019Article
- Exploration of the regulation and control mechanisms of miR-145 in trophoblast cell proliferation and invasion.Experimental and therapeutic medicine · 2018Article
- Shifting perspectives from "oncogenic" to oncofetal proteins; how these factors drive placental development.Reproductive biology and endocrinology : RB&E · 2018Review
- Up-regulation of microRNA-202-3p in first trimester placenta of pregnancies destined to develop severe preeclampsia, a pilot study.Pregnancy hypertension · 2017Article
- Role of microRNAs in translation regulation and cancer.World journal of biological chemistry · 2017Review
- High-throughput deep screening and identification of four peripheral leucocyte microRNAs as novel potential combination biomarkers for preeclampsia.Journal of perinatology : official journal of the California Perinatal Association · 2016Article
- Potential role of epigenetic mechanisms in regulation of trophoblast differentiation, migration, and invasion in the human placenta.Cell adhesion & migration · 2016Review
- Associations of blood pressure in pregnancy with offspring blood pressure trajectories during childhood and adolescence: findings from a prospective study.Journal of the American Heart Association · 2015Article
- The imbalance in expression of angiogenic and anti-angiogenic factors as candidate predictive biomarker in preeclampsia.Iranian journal of reproductive medicine · 2015Review
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Strong evidence suggests a potential link among epigenetics, microRNAs (miRNAs), and pregnancy complications. Much research still needs to be carried out to determine whether epigenetic factors are predictive in the pathogenesis of preeclampsia (PE), a life-threatening disease during pregnancy. Recently, the importance of maternal epigenetic features, including DNA methylation, histone modifications, epigenetically regulated miRNA, and the effect of imprinted or non-imprinted genes on trophoblast growth, invasion, as well as fetal development and hypertension in pregnancy, has been demonstrated in a series of articles. This article discusses the current evidence of this complicated network of miRNA and epigenetic factors as potential mechanisms that may underlie the theories of disease for PE. Translating these basic epigenetic findings to clinical practice could potentially serve as prognostic biomarkers for diagnosis in its early stages and could help in the development of prophylactic strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.