Evidence map›Paper›PMID 22468820›Full record

ReviewExpert review of molecular diagnostics2012

Progress in circulating tumor cell capture and analysis: implications for cancer management.

Marija Balic, Henry Lin, Anthony Williams, Ram H Datar, Richard J Cote

Abstract readReview
In one paragraph

Review in Expert review of molecular diagnostics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. miR-205-5p Downregulation andInternational journal of molecular sciences · 2021
    Article
  5. Article
  6. Review
  7. Photoacoustic detection of circulating melanoma cells in late stage patients.Journal of innovative optical health sciences · 2020
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Genomic and Epigenomic Alterations in Cancer.The American journal of pathology · 2016
    Review
  17. Interaction between circulating cancer cells and platelets: clinical implication.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2015
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Marija BalicDivision of Oncology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria. marija.balic@medunigraz.at
Henry Lin
Anthony Williams
Ram H Datar
Richard J Cote

Funding

Circulating Tumor Cell Capture & Analysis in a Multi-Center Prostate Cancer TrialR01CA141077 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI COTE, RICHARD JAMES · 2009 to 2013
$1.9M
Integrated Microdevice to Capture and Detect Circulating Tumor CellsR33CA123027 · NCI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI COTE, RICHARD JAMES · 2010 to 2011
$1.1M
Integrated Microdevice to Capture and Detect Circulating Tumor CellsR21CA123027 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI COTE, RICHARD JAMES · 2006 to 2007
$333k
NCI NIH HHS CA-123027NCI NIH HHS R01 CA141077NCI NIH HHS R21 CA123027NCI NIH HHS R33 CA123027
6 · The paper itself

Abstract

The hematogenous dissemination of cancer and development of distant metastases is the cause of nearly all cancer deaths. Detection of circulating tumor cells (CTCs) as a surrogate biomarker of metastases has gained increasing interest. There is accumulating evidence on development of novel technologies for CTC detection, their prognostic relevance and their use in therapeutic response monitoring. Many clinical trials in the early and metastatic cancer setting, particularly in breast cancer, are including CTCs in their translational research programs and as secondary end points. We summarize the progress of detection methods in the context of their clinical importance and speculate on the possibilities of wider implementation of CTCs as a diagnostic oncology tool, the likelihood that CTCs will be used as a useful biomarker, especially to monitor therapeutic response, and what may be expected from the future improvements in technologies.

Indexed as

Neoplastic Cells, CirculatingBiomarkers, TumorBreast NeoplasmsDisease ManagementEpithelial-Mesenchymal TransitionFemaleHumansNeoplasm MetastasisNeoplastic Stem CellsBiomarkers, Tumor

Identifiers

PMID22468820
PMCPMC3391569

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.