ArticleExpert review of molecular diagnostics2012
Screening for latent infection with Mycobacterium tuberculosis: a plea for targeted testing in low endemic regions.
Article in Expert review of molecular diagnostics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The higher specificity proposed for IFN-γ-release assays (IGRAs) compared with tuberculin skin testing (TST) may indicate superiority in identifying patients at risk for progression towards active tuberculosis. Unfortunately, available assays may frequently show discordant results. To aid in interpreting discordant results, the article under evaluation has comparatively analyzed results of the TST and two commercially available IGRAs in a low-risk population for tuberculosis. TST-positive/IGRA-negative results were strongly associated with bacillus Calmette-Guérin vaccination or nontuberculous mycobacteria sensitization, whereas the etiology of TST-negative/IGRA-positive results or discrepancies among IGRAs remain unresolved. As the three tests identified different individuals in the majority of positive cases, this indicates that most positive results obtained in the absence of additional risk factors are falsely positive. By contrast, increasing concordance of positive results was associated with tuberculosis risk factors. This has direct implications for screening practices in low prevalence regions where a targeted screening approach may reduce both unnecessary testing and treatment.
Identifiers
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Registered trials
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