Evidence map›Paper›PMID 22468688›Full record

ArticleJournal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)2013

Supportive family environments, genes that confer sensitivity, and allostatic load among rural African American emerging adults: a prospective analysis.

Gene H Brody, Tianyi Yu, Yi-fu Chen, Steven M Kogan, Gary W Evans, Michael Windle, Meg Gerrard, Frederick X Gibbons, Ronald L Simons, Robert A Philibert

Abstract read
In one paragraph

Article in Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Article
  7. Article
  8. The Early Growth and Development Study: A Dual-Family Adoption Study from Birth Through Adolescence.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019
    Article
  9. Article
  10. Article
  11. Article
  12. Naturalistic Experimental Designs as Tools for Understanding the Role of Genes and the Environment in Prevention Research.Prevention science : the official journal of the Society for Prevention Research · 2018
    Article
  13. Risky family processes prospectively forecast shorter telomere length mediated through negative emotions.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2017
    Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Neighborhood Poverty, College Attendance, and Diverging Profiles of Substance Use and Allostatic Load in Rural African American Youth.Clinical psychological science : a journal of the Association for Psychological Science · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Gene H BrodyCenter for Family Research, University of Georgia, Athens, GA 30602-4527, USA. gbrody@uga.edu
Tianyi Yu
Yi-fu Chen
Steven M Kogan
Gary W Evans
Michael Windle
Meg Gerrard
Frederick X Gibbons
Ronald L Simons
Robert A Philibert
University of Georgia · USDartmouth College · USCornell University · USEmory University · USUniversity of Iowa · US

Funding

RURAL AFRICAN AMERICAN YOUNG ADULTS' PATHWAYS TO PSYCHOSOCIAL AND PHYSICAL HEALTHR01HD030588 · NICHD · UNIVERSITY OF GEORGIA (UGA) · PI EHRLICH, KATHERINE BABCOCK · 1993 to 2023
$12.0M
Vulnerability to Drug Use & HIV: Advancing Prevention for Rural African AmericansP30DA027827 · NIDA · UNIVERSITY OF GEORGIA · PI BRODY, GENE H. · 2009 to 2018
$10.2M
The Development of Alcohol Use and Alcohol Disorders Across the LifespanK05AA021143 · NIAAA · EMORY UNIVERSITY · PI WINDLE, MICHAEL T · 2012 to 2016
$1.0M
NIAAA NIH HHS K05 AA021143NICHD NIH HHS R01 HD030588NICHD NIH HHS R01HD030588NIDA NIH HHS P30 DA027827NIDA NIH HHS P30DA027827
6 · The paper itself

Abstract

The purpose of this study was to investigate interactions between exposure to supportive family environments and genetic characteristics, which were hypothesized to forecast variations in allostatic load (AL) in a representative sample of 315 rural African American youths. Data on family environments were gathered when youths were 11-13, and genetic data were collected when they were 16, years of age. Data on AL were obtained at the beginning of emerging adulthood, age 19 years. The data analyses revealed that, as predicted, emerging adults exposed to less supportive family environments across preadolescence manifested higher levels of AL when they carried the short (s) allele at the 5-HTTLPR and an allele of DRD4 with seven or more repeats. This is an E(family environment) × G(5-HTTLPR status) × G(DRD4 status) interaction. These data suggest that African American youths carrying genes that confer sensitivity who are exposed to less supportive family environments may be at greater risk for adverse physical health consequences that AL presages.

Indexed as

AllostasisBlack or African AmericanFamily RelationsGene-Environment InteractionAdolescentAdultChildHumansProspective StudiesReceptors, Dopamine D4Rural PopulationSerotonin Plasma Membrane Transport ProteinsSocial SupportYoung AdultDRD4 protein, humanReceptors, Dopamine D4Serotonin Plasma Membrane Transport ProteinsSLC6A4 protein, human

Identifiers

PMID22468688
PMCPMC3390435
OpenAlexW1976344380

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.