ArticleThe Journal of rheumatology2012
Increased incidence and impact of upper and lower gastrointestinal events in patients with rheumatoid arthritis in Olmsted County, Minnesota: a longitudinal population-based study.
Article in The Journal of rheumatology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 29 citations in OpenAlex.
- The Association between Absence of Abdominal Pain and Mortality in Lower Intestinal Perforation in Patients with Autoimmune Rheumatic Diseases.BioMed research international · 2019Trial
- Complications of Catheter Ablation for Atrial Fibrillation in Patients with Rheumatic Diseases.Journal of clinical medicine · 2026Article
- Therapeutic Dose of Zinc Aspartate and Zinc Citrate Attenuates Disease Activity Indices in Rheumatoid Arthritis.Biological trace element research · 2025Article
- Rheumatoid Arthritis and Atrial Fibrillation: a Complex Cardiovascular Intersection - Insights from a Retrospective Cohort Study.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2025Article
- Prevalence, Causes and Outcomes of Acute Gastrointestinal Bleeding in Rheumatoid Arthritis: A Systematic Review and Meta-Analysis.Mediterranean journal of rheumatology · 2024Article
- Low Frequency of Upper Gastrointestinal Bleeding Despite Non-Steroidal Anti-Inflammatory Drugs and Corticosteroids in Patients with Rheumatoid Arthritis.Current rheumatology reviews · 2024Article
- Prevalence and Determinants of Gastrointestinal Manifestations in Patients with Selected Rheumatologic Diseases.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022Article
- Rheumatoid Arthritis in Silica-Exposed Workers.International journal of environmental research and public health · 2021Article
- Article
- Sex differences in risk factors of uncomplicated colonic diverticulosis in a metropolitan area from Northern China.Scientific reports · 2018Article
- Risk of gastrointestinal events among patients with sarcoidosis: a population-based study 1976-2013.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2018Article
- Risk for lower intestinal perforations in patients with rheumatoid arthritis treated with tocilizumab in comparison to treatment with other biologic or conventional synthetic DMARDs.Annals of the rheumatic diseases · 2017Observational
- Incidence of Gastrointestinal Perforations in Patients with Rheumatoid Arthritis Treated with Tocilizumab from Clinical Trial, Postmarketing, and Real-World Data Sources.Rheumatology and therapy · 2016Article
- Brief Report: Risk of Gastrointestinal Perforation Among Rheumatoid Arthritis Patients Receiving Tofacitinib, Tocilizumab, or Other Biologic Treatments.Arthritis & rheumatology (Hoboken, N.J.) · 2016Article
- Breath Methane Levels Are Increased Among Patients with Diverticulosis.Digestive diseases and sciences · 2016Article
- Intake of high-fructose corn syrup sweetened soft drinks, fruit drinks and apple juice is associated with prevalent arthritis in US adults, aged 20-30 years.Nutrition & diabetes · 2016Article
- Hospitalization rates and utilization among patients with rheumatoid arthritis: a population-based study from 1987 to 2012 in Olmsted County, Minnesota.Mayo Clinic proceedings · 2015Article
- A Case of Diverticular Perforation in a Young Patient with Rheumatoid Arthritis on Methotrexate.Case reports in medicine · 2015Article
- Occurrence and effect of lower extremity ulcer in rheumatoid arthritis -- a population-based Study.The Journal of rheumatology · 2014Article
- Aspirin use in rheumatoid arthritis patients with increased risk of cardiovascular disease.ISRN rheumatology · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 4 countries.
Funding
Abstract
objectiveTo assess the incidence and mortality impact of upper and lower gastrointestinal (GI) events in rheumatoid arthritis (RA) compared to non-RA subjects.
methodsWe identified incident upper and lower GI events and estimated their incidence rates using person-year methods in a population-based incident RA cohort of residents of Olmsted County, Minnesota, USA (1987 American College of Rheumatology criteria first fulfilled between January 1, 1980, and January 1, 2008) and non-RA subjects from the same population.
resultsThe study included 813 patients with RA and 813 non-RA subjects (mean followup 10.3 and 10.8 yrs, respectively); 68% women; mean age 55.9 yrs in both cohorts. The rate of upper GI events/100 person-years was 2.9 in RA versus 1.7 in the non-RA cohort (rate ratio 1.7, 95% CI 1.4, 2.2); for lower GI events, the rates were 2.1 in RA versus 1.4 in the non-RA cohort (rate ratio 1.5, 95% CI 1.1, 1.9). The incidence of upper GI bleed, perforation, ulcer, obstruction, and any upper GI event in RA declined over calendar time; the incidence of lower GI events remained unchanged. Exposure to glucocorticoids, prior upper GI disease, abdominal surgery, and smoking were associated with lower GI events in RA. Both upper and lower GI events were associated with increased mortality risk in RA.
conclusionThere is increased risk of serious upper and lower GI events in RA compared to non-RA subjects, and increased GI-related mortality in RA. Prominent declines in incidence of upper, but not lower GI events in RA highlight the need for studies investigating lower GI disease in patients with RA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.