ArticleJournal of immunology (Baltimore, Md. : 1950)2012
Differential transcription factor use by the KIR2DL4 promoter under constitutive and IL-2/15-treated conditions.
Article in Journal of immunology (Baltimore, Md. : 1950), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Bioinformatic Analysis of the Significance of the KIR2DL4 Gene in Recurrent Implantation Failure.Biochemical genetics · 2025Article
- Transcriptional and post-transcriptional regulation of NK cell development and function.Clinical immunology (Orlando, Fla.) · 2017Review
- Killer-cell immunoglobulin-like receptor genes and ligands and their role in hematologic malignancies.Cancer immunology, immunotherapy : CII · 2016Review
- Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation.Molecular and cellular biology · 2014Article
- IL-2/IL-15 activate the human clonally restricted KIR3DL1 reverse promoter.Genes and immunity · 2013Article
- Article
- KIR2DL5: An Orphan Inhibitory Receptor Displaying Complex Patterns of Polymorphism and Expression.Frontiers in immunology · 2012Article
- Human natural killer cell microRNA: differential expression of MIR181A1B1 and MIR181A2B2 genes encoding identical mature microRNAs.Genes and immunityArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
KIR2DL4 is unique among human KIR genes in expression, cellular localization, structure, and function, yet the transcription factors required for its expression have not been identified. Using mutagenesis, EMSA, and cotransfection assays, we identified two redundant Runx binding sites in the 2DL4 promoter as essential for constitutive 2DL4 transcription, with contributions by a cyclic AMP response element (CRE) and initiator elements. IL-2- and IL-15-stimulated human NK cell lines increased 2DL4 promoter activity, which required functional Runx, CRE, and Ets sites. Chromatin immunoprecipitation experiments show that Runx3 and Ets1 bind the 2DL4 promoter in situ. 2DL4 promoter activity had similar transcription factor requirements in T cells. Runx, CRE, and Ets binding motifs are present in 2DL4 promoters from across primate species, but other postulated transcription factor binding sites are not preserved. Differences between 2DL4 and clonally restricted KIR promoters suggest a model that explains the unique 2DL4 expression pattern in human NK cells.
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Registered trials
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