Evidence map›Paper›PMID 22467628›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2012

Microfluidic generation of acoustically active nanodroplets.

Thomas D Martz, David Bardin, Paul S Sheeran, Abraham P Lee, Paul A Dayton

Abstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Acoustically Activatable Drug-Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Review
  4. Investigation of Phase-Change Droplets and Fast Imaging for Indicator Dilution Measurement of Flow.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Methods of Generating Submicrometer Phase-Shift Perfluorocarbon Droplets for Applications in Medical Ultrasonography.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017
    Article
  15. Article
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Thomas D MartzCurriculum of Applied Science & Engineering - Material Science, University of North Carolina, 310 Taylor Hall, CB 7575, Chapel Hill, NC 27599, USA.
David Bardin
Paul S Sheeran
Abraham P Lee
Paul A Dayton

Funding

Precision engineering of ultrasonically-targeted drug delivery vehiclesR01EB008733 · NIBIB · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI DAYTON, PAUL A · 2009 to 2012
$1.3M
Pro-Bubbles for Ultrasound Imaging and Treatment of Prostate CancerR21EB011704 · NIBIB · UNIVERSITY OF ARIZONA · PI MATSUNAGA, TERRY ONICHI · 2010 to 2011
$412k
NIBIB NIH HHS R01 EB008733NIBIB NIH HHS R01EB008733NIBIB NIH HHS R21 EB011704NIBIB NIH HHS R21EB011704
6 · The paper itself

Abstract

A microfluidic approach for the generation of perfluorocarbon nanodroplets as the primary emulsion with diameters as small as 300-400 nm is described. The system uses a pressure-controlled delivery of all reagents and increased viscosity in the continuous phase to drive the device into an advanced tip-streaming regime, which results in generation of droplets in the sub-micrometer range. Such nanodroplets may be appropriate for emerging biomedical applications.

Indexed as

Microfluidic Analytical TechniquesMicrofluidicsAcousticsDrug Delivery SystemsEquipment DesignFluorocarbonsGlycerolLymphatic SystemMicroscopyMicroscopy, Electron, TransmissionNanotechnologyOptics and PhotonicsParticle SizePressureViscosityFluorocarbonsGlycerol

Identifiers

PMID22467628
PMCPMC3658617

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.