ArticleInflammatory bowel diseases2013
Surgical outcome of ileal pouch-anal anastomosis when used intentionally for well-defined Crohn's disease.
Article in Inflammatory bowel diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- Anti-OmpC antibodies in Crohn's disease and ulcerative colitis: evidence from a systematic review and meta-analysis.Crohn's & colitis 360 · 2026Article
- Secure Ileal Pouch-Anal Anastomosis for Histologic Indeterminate Colitis.Journal of clinical medicine · 2025Article
- Ubiquitous Colonic Ileal Metaplasia Consistent with the Diagnosis of Crohn's Colitis among Indeterminate Colitis Cohorts.Medical research archives · 2023Article
- Anastomotic Considerations in Crohn's Disease.Clinics in colon and rectal surgery · 2023Review
- Crohn's of the Pouch: Now What?Clinics in colon and rectal surgery · 2022Review
- State-of-the-art surgery for Crohn's disease: Part II-colonic Crohn's disease and associated neoplasms.Langenbeck's archives of surgery · 2022Review
- Clinicopathological Characteristics and Surgical Outcomes of Crohn Disease-Associated Colorectal Malignancy.Annals of coloproctology · 2021Article
- Modern surgical strategies for perianal Crohn's disease.World journal of gastroenterology · 2020Review
- Inflammatory bowel disease position statement of the Italian Society of Colorectal Surgery (SICCR): Crohn's disease.Techniques in coloproctology · 2020Review
- The MYTHS ofJapanese journal of gastroenterology and hepatology · 2020Article
- Comparison of long-term outcomes of primary and redo IPAA for patients with Crohn's disease.International journal of colorectal disease · 2019Article
- Is There a Role for Ileal Pouch Anal Anastomosis in Crohn's Disease?Clinics in colon and rectal surgery · 2019Review
- Adenocarcinoma at the Ileostomy Site After a Proctocolectomy for Ulcerative Colitis and/or Familial Adenomatous Polyposis: An Overview.Ostomy/wound management · 2018Review
- When Not to Pouch: Important Considerations for Patient Selection for Ileal Pouch-Anal Anastomosis.Gastroenterology & hepatology · 2017Article
- Human alpha defensin 5 is a candidate biomarker to delineate inflammatory bowel disease.PloS one · 2017Article
- Indications and surgical options for small bowel, large bowel and perianal Crohn's disease.World journal of gastroenterology · 2016Review
- Common Inflammatory Disorders and Neoplasia of the Ileal Pouch: A Review of Histopathology.Gastroenterology research · 2016Review
- Colectomy with Permanent End Ileostomy Is More Cost-Effective than Ileal Pouch-Anal Anastomosis for Crohn's Colitis.Digestive diseases and sciences · 2016Article
- Diagnostic and Prognostic Microbial Biomarkers in Inflammatory Bowel Diseases.Gastroenterology · 2015Review
- Identification of pathologic features associated with "ulcerative colitis-like" Crohn's disease.World journal of gastroenterology · 2014Article
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundCrohn's disease (CD) is considered a contraindication to ileal pouch--anal anastomosis (IPAA). In this study, we compare outcomes of CD and ulcerative colitis (UC) patients undergoing IPAA.
methodsPatients were considered to have CD before surgery based on a history of small bowel disease, perianal disease, noncrypt-associated granuloma, or pretreatment skip colonic lesions. Patients were prospectively assessed for pouchitis or CD. Postoperative CD (pouch inflammation into the afferent limb or pouch fistula) or pouch failure (need for permanent diversion) were assessed. Preoperative serum was assayed for IBD-associated antibodies using enzyme-linked immunosorbent assay (ELISA).
resultsSeventeen patients with preoperative CD were identified. Seven (41%) patients developed postoperative recurrent CD in the afferent limb (n = 3) or pouch fistulizing disease (n = 4). One patient (6%) required pouch excision. The incidence of postoperative CD was higher (P = 0.002) in preoperative CD patients (41%) than UC patients (11%). There was no significant difference in pouchitis or pouch failure. There was also no significant difference in any preoperative clinical feature between patients with or without postoperative CD. Afferent limb inflammation developed in three (50%) of the six patients with pANCA+/OmpC- expression compared to none of the 11 patients without this serologic profile (P = 0.03).
conclusionsAlthough the intentional use of IPAA in CD has a higher incidence of postoperative disease vs. UC patients, there was no significant difference in pouch failure. Demographics, clinical features, and serologic factors do not predict outcome of CD patients undergoing IPAA. IBD serology may identify the phenotype manifestation of postoperative recurrent CD.
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