ArticleApplied and environmental microbiology2012
High-throughput sequence-based analysis of the intestinal microbiota of weanling pigs fed genetically modified MON810 maize expressing Bacillus thuringiensis Cry1Ab (Bt maize) for 31 days.
Article in Applied and environmental microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- Impact of herbicide-resistant genetically modified rapeseed on gut bacterial diversity ofGM crops & food · 2026Article
- Modulation of Swine Gut Microbiota by Phytogenic Blends and High Concentrations of Casein in a Validated Swine Large Intestinal In Vitro Model.Veterinary sciences · 2023Article
- Donor age and body weight determine the effects of fecal microbiota transplantation on growth performance, and fecal microbiota development in recipient pigs.Journal of animal science and biotechnology · 2022Article
- Effects of a multi-strain probiotic on growth, health, and fecal bacterial flora of neonatal dairy calves.Animal bioscience · 2022Article
- Intestinal microbiota modulation and improved growth in pigs with post-weaning antibiotic and ZnO supplementation but only subtle microbiota effects with Bacillus altitudinis.Scientific reports · 2021Article
- A Novel Corn-Expressed Phytase Improves Daily Weight Gain, Protein Efficiency Ratio and Nutrients Digestibility and Alters Fecal Microbiota in Pigs Fed with Very Low Protein Diets.Animals : an open access journal from MDPI · 2020Article
- Effect of cereal fermentation and carbohydrase supplementation on growth, nutrient digestibility and intestinal microbiota in liquid-fed grow-finishing pigs.Scientific reports · 2020Article
- Heritability and genome-wide association of swine gut microbiome features with growth and fatness parameters.Scientific reports · 2020Article
- Early-Life Intake of an Isotonic Protein Drink Improves the Gut Microbial Profile of Piglets.Animals : an open access journal from MDPI · 2020Article
- Effect of cereal soaking and carbohydrase supplementation on growth, nutrient digestibility and intestinal microbiota in liquid-fed grow-finishing pigs.Scientific reports · 2020Article
- Improvement of Feed Efficiency in Pigs through Microbial Modulation via Fecal Microbiota Transplantation in Sows and Dietary Supplementation of Inulin in Offspring.Applied and environmental microbiology · 2019Article
- Article
- The Chronic Effect of Transgenic Maize Line withMicroorganisms · 2019Article
- Beneficial roles of probiotics on the modulation of gut microbiota and immune response in pigs.PloS one · 2019Article
- Characterization of the Early Life Microbiota Development and PredominantFrontiers in microbiology · 2019Article
- High-throughput Sequencing-based Analysis of the Intestinal Microbiota of Broiler Chickens Fed Genetically Modified Rice Expressing Cry1Ac/Cry1Ab ChimericThe journal of poultry science · 2018Article
- Changes of gut microbiota structure and morphology in weaned piglets treated with fresh fermented soybean meal.World journal of microbiology & biotechnology · 2017Article
- Exploring a Possible Link between the Intestinal Microbiota and Feed Efficiency in Pigs.Applied and environmental microbiology · 2017Article
- Changes in the colon microbiota and intestinal cytokine gene expression following minimal intestinal surgery.World journal of gastroenterology · 2015Article
- In situ prebiotics for weaning piglets: in vitro production and fermentation of potato galacto-rhamnogalacturonan.Applied and environmental microbiology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to investigate if feeding genetically modified (GM) MON810 maize expressing the Bacillus thuringiensis insecticidal protein (Bt maize) had any effects on the porcine intestinal microbiota. Eighteen pigs were weaned at ~28 days and, following a 6-day acclimatization period, were assigned to diets containing either GM (Bt MON810) maize or non-GM isogenic parent line maize for 31 days (n = 9/treatment). Effects on the porcine intestinal microbiota were assessed through culture-dependent and -independent approaches. Fecal, cecal, and ileal counts of total anaerobes, Enterobacteriaceae, and Lactobacillus were not significantly different between pigs fed the isogenic or Bt maize-based diets. Furthermore, high-throughput 16S rRNA gene sequencing revealed few differences in the compositions of the cecal microbiotas. The only differences were that pigs fed the Bt maize diet had higher cecal abundance of Enterococcaceae (0.06 versus 0%; P < 0.05), Erysipelotrichaceae (1.28 versus 1.17%; P < 0.05), and Bifidobacterium (0.04 versus 0%; P < 0.05) and lower abundance of Blautia (0.23 versus 0.40%; P < 0.05) than pigs fed the isogenic maize diet. A lower enzyme-resistant starch content in the Bt maize, which is most likely a result of normal variation and not due to the genetic modification, may account for some of the differences observed within the cecal microbiotas. These results indicate that Bt maize is well tolerated by the porcine intestinal microbiota and provide additional data for safety assessment of Bt maize. Furthermore, these data can potentially be extrapolated to humans, considering the suitability of pigs as a human model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.