ReviewAmerican journal of physiology. Heart and circulatory physiology2012
Mechanisms of ventricular arrhythmias: a dynamical systems-based perspective.
Review in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- For Whom the Bell Tolls : Refining Risk Assessment for Sudden Cardiac Death.Current cardiology reports · 2019Pooled it
- Replacement fibrosis, left ventricular ejection fraction and sudden cardiac death in patients after myocardial infarction: a mediation analysis.Open heart · 2026Article
- Ventricular arrhythmias in the context of chronic kidney disease and electrolyte imbalance.Herzschrittmachertherapie & Elektrophysiologie · 2024Review
- Arrhythmias and cardiac MRI associations in patients with established cardiac dystrophinopathy.Open heart · 2024Article
- Anti-Arrhythmic Effects of Heart Failure Guideline-Directed Medical Therapy and Their Role in the Prevention of Sudden Cardiac Death: From Beta-Blockers to Sodium-Glucose Cotransporter 2 Inhibitors and Beyond.Journal of clinical medicine · 2024Review
- A comprehensive protocol combining in vivo and ex vivo electrophysiological experiments in an arrhythmogenic animal model.American journal of physiology. Heart and circulatory physiology · 2024Article
- Vericiguat suppresses ventricular tachyarrhythmias inducibility in a rabbit myocardial infarction model.PloS one · 2024Article
- Prognostic Significance of Different Ventricular Ectopic Burdens During Submaximal Exercise in Asymptomatic UK Biobank Subjects.Circulation · 2023Article
- Global Air Pollutant Phenanthrene and Arrhythmic Outcomes in a Mouse Model.Environmental health perspectives · 2023Article
- Implantable cardioverter defibrillator for primary prevention in patients with non-ischemic cardiomyopathy in the era of novel therapeutic agents- meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- A machine-learning approach for long-term prediction of experimental cardiac action potential time series using an autoencoder and echo state networks.Chaos (Woodbury, N.Y.) · 2022Article
- Arrhythmia prevalence and sudden death risk in adults with the m.3243A>G mitochondrial disorder.Open heart · 2022Article
- Deterministic and Stochastic Cellular Mechanisms Contributing to Carbon Monoxide Induced Ventricular Arrhythmias.Frontiers in pharmacology · 2021Article
- Network Pharmacology-Based Systematic Analysis of Molecular Mechanisms of Dingji Fumai Decoction for Ventricular Arrhythmia.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Elevated plasma levels of asymmetric dimethylarginine and the risk for arrhythmic death in ischemic and non-ischemic, dilated cardiomyopathy - A prospective, controlled long-term study.Clinical biochemistry · 2020Observational
- The Ubiquitous Premature Ventricular Complex.Cureus · 2020Review
- Shensong Yangxin Protects Against Metabolic Syndrome-Induced Ventricular Arrhythmias by Inhibiting Electrical Remodeling.Frontiers in pharmacology · 2020Article
- Phase Entrainment of Induced Ventricular Fibrillation: A Human Feasibility and Proof of Concept Study.Journal of atrial fibrillation · 2019Article
- In vitro analyses of suspected arrhythmogenic thin filament variants as a cause of sudden cardiac death in infants.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Large-scale Interactive Numerical Experiments of Chaos, Solitons and Fractals in Real Time via GPU in a Web Browser.Chaos, solitons, and fractals · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Defining the cellular electrophysiological mechanisms for ventricular tachyarrhythmias is difficult, given the wide array of potential mechanisms, ranging from abnormal automaticity to various types of reentry and kk activity. The degree of difficulty is increased further by the fact that any particular mechanism may be influenced by the evolving ionic and anatomic environments associated with many forms of heart disease. Consequently, static measures of a single electrophysiological characteristic are unlikely to be useful in establishing mechanisms. Rather, the dynamics of the electrophysiological triggers and substrates that predispose to arrhythmia development need to be considered. Moreover, the dynamics need to be considered in the context of a system, one that displays certain predictable behaviors, but also one that may contain seemingly stochastic elements. It also is essential to recognize that even the predictable behaviors of this complex nonlinear system are subject to small changes in the state of the system at any given time. Here we briefly review some of the short-, medium-, and long-term alterations of the electrophysiological substrate that accompany myocardial disease and their potential impact on the initiation and maintenance of ventricular arrhythmias. We also provide examples of cases in which small changes in the electrophysiological substrate can result in rather large differences in arrhythmia outcome. These results suggest that an interrogation of cardiac electrical dynamics is required to provide a meaningful assessment of the immediate risk for arrhythmia development and for evaluating the effects of putative antiarrhythmic interventions.
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