ArticleEuropean biophysics journal : EBJ2012
On the biophysics of cathodal galvanotaxis in rat prostate cancer cells: Poisson-Nernst-Planck equation approach.
Article in European biophysics journal : EBJ, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Voltage-gated sodium channels: from roles and mechanisms in the metastatic cell behavior to clinical potential as therapeutic targets.Frontiers in pharmacology · 2023Review
- Altered β-Cell Calcium Dynamics via Electric Field Exposure.Annals of biomedical engineering · 2021Article
- Electric Fields at Breast Cancer and Cancer Cell Collective Galvanotaxis.Scientific reports · 2020Article
- Bioelectric Control of Metastasis in Solid Tumors.Bioelectricity · 2019Article
- Transmembrane voltage potential of somatic cells controls oncogene-mediated tumorigenesis at long-range.Oncotarget · 2014Article
- In vitro and in vivo neuronal electrotaxis: a potential mechanism for restoration?Molecular neurobiology · 2014Review
- The role of passive calcium influx through the cell membrane in galvanotaxis.Cellular & molecular biology letters · 2013Article
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Abstract
Rat prostate cancer cells have been previously investigated using two cell lines: a highly metastatic one (Mat-Ly-Lu) and a nonmetastatic one (AT-2). It turns out that the highly metastatic Mat-Ly-Lu cells exhibit a phenomenon of cathodal galvanotaxis in an electric field which can be blocked by interrupting the voltage-gated sodium channel (VGSC) activity. The VGSC activity is postulated to be characteristic for metastatic cells and seems to be a reasonable driving force for motile behavior. However, the classical theory of cellular motion depends on calcium ions rather than sodium ions. The current research provides a theoretical connection between cellular sodium inflow and cathodal galvanotaxis of Mat-Ly-Lu cells. Electrical repulsion of intracellular calcium ions by entering sodium ions is proposed after depolarization starting from the cathodal side. The disturbance in the calcium distribution may then drive actin polymerization and myosin contraction. The presented modeling is done within a continuous one-dimensional Poisson-Nernst-Planck equation framework.
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