ReviewMolecules (Basel, Switzerland)2012
Chemistry and biological activities of terpenoids from copaiba (Copaifera spp.) oleoresins.
Review in Molecules (Basel, Switzerland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05308732 (Phase I Study of Multiple Ascending Dose, to Investigate the Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy), which is not on this map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Phase I Study of Multiple Ascending Dose, to Investigate the Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy
Who cites it
47 citing papers in PubMed, 259 citations in OpenAlex.
- Effect of copaiba oil-resin on dental sensitivity control and color change after bleaching: A randomized clinical trial.Clinical oral investigations · 2025Trial
- Chemical Profiling and Biological Activity of Copaiba Oil-Resin Samples and Development of HPLC-DAD Method for the Analysis of β-Caryophyllene.Biomedical chromatography : BMC · 2026Article
- Seasonal Dynamics of the Essential Oil Constituents from the Aerial Parts ofPlants (Basel, Switzerland) · 2026Article
- Article
- Combined potential of copaifera officinalis oleoresin and chitosan against oral pathogens.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Insecticidal and Repellent Activity of Essential Oils from Copaifera reticulata, Citrus paradisi, Lavandula hybrida and Salvia sclarea Against Immature and Adult Stages of Ctenocephalides felis felis.Acta parasitologica · 2024Article
- Antibacterial, antibiofilm, and antivirulence potential of the main diterpenes from Copaifera spp. oleoresins against multidrug-resistant bacteria.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Copaiba oil's bactericidal activity and its effects on health and zootechnical performance for Nile tilapia after oral supplementation.Scientific reports · 2024Article
- Copaiba oil minimizes inflammation and promotes parenchyma re-epithelization in acute allergic asthma model induced by ovalbumin in BALB/c mice.Frontiers in pharmacology · 2024Article
- Chemodiversity and Bioactivity of the Essential Oils ofInternational journal of molecular sciences · 2023Article
- Polyalthic Acid fromPharmaceuticals (Basel, Switzerland) · 2023Article
- Synthesis and Antibacterial Activity of Polyalthic Acid Analogs.Antibiotics (Basel, Switzerland) · 2023Article
- Chemical Characterization and Quality Assessment of Copaiba Oil-Resin Using GC/MS and SFC/MS.Plants (Basel, Switzerland) · 2023Article
- Toxicological Effects of Copaiba Oil (Plants (Basel, Switzerland) · 2023Review
- Copaiba Oil-Loaded Polymeric Nanocapsules: Production and In Vitro Biosafety Evaluation on Lung Cells as a Pre-Formulation Step to Produce Phytotherapeutic Medicine.Pharmaceutics · 2023Article
- Design and Optimization of a Natural Medicine fromPolymers · 2022Article
- Anti-inflammatory and wound healing effect of Copaiba oleoresin on the oral cavity: A systematic review.Heliyon · 2022Review
- Induced oral mucositis in Wistar rats treated with different drugs: Preventive potential in cytokine production.Molecular and clinical oncology · 2021Article
- Article
- Investigation ofFuture science OA · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Copaiba oleoresins are exuded from the trunks of trees of the Copaifera species (Leguminosae-Caesalpinoideae). This oleoresin is a solution of diterpenoids, especially, mono- and di-acids, solubilized by sesquiterpene hydrocarbons. The sesquiterpenes and diterpenes (labdane, clerodane and kaurane skeletons) are different for each Copaifera species and have been linked to several reported biological activities, ranging from anti-tumoral to embriotoxic effects. This review presents all the substances already described in this oleoresin, together with structures and activities of its main terpenoids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.