ArticleNature methods2012
Direct visualization of specifically modified extracellular glycans in living animals.
Article in Nature methods, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Engineering, Expression, Purification, and Application of Glycosaminoglycan-Specific Antibodies.Current protocols · 2026Article
- Review
- Article
- A glycan-based approach to cell characterization and isolation: Hematopoiesis as a paradigm.The Journal of experimental medicine · 2022Article
- Imaging Glycosaminoglycan Modification Patterns In Vivo.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The HSPG syndecan is a core organizer of cholinergic synapses.The Journal of cell biology · 2021Article
- Article
- Article
- Heparan Sulfate Proteoglycans as Emerging Players in Synaptic Specificity.Frontiers in molecular neuroscience · 2018Review
- Applying DNA rolling circle amplification in fluorescence imaging of cell surface glycans labeled by a metabolic method.Chemical science · 2016Article
- Conservation of anatomically restricted glycosaminoglycan structures in divergent nematode species.Glycobiology · 2016Article
- Directional Trans-Synaptic Labeling of Specific Neuronal Connections in Live Animals.Genetics · 2015Article
- A transgenic approach to live imaging of heparan sulfate modification patterns.Methods in molecular biology (Clifton, N.J.) · 2015Article
- The cellular and molecular mechanisms of vertebrate lens development.Development (Cambridge, England) · 2014Review
- Complex cooperative functions of heparan sulfate proteoglycans shape nervous system development in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2014Article
- Syndecan promotes axon regeneration by stabilizing growth cone migration.Cell reports · 2014Article
- Heparan sulfate 3-O-sulfation: a rare modification in search of a function.Matrix biology : journal of the International Society for Matrix Biology · 2014Review
- Blood vessels pattern heparan sulfate gradients between their apical and basolateral aspects.PloS one · 2014Article
- Chemical probing of glycans in cells and organisms.Chemical Society reviews · 2013Review
- Distinct 3-O-sulfated heparan sulfate modification patterns are required for kal-1-dependent neurite branching in a context-dependent manner in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2013Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Modification patterns of heparan sulfate coordinate protein function in metazoans, yet in vivo imaging of such non-genetically encoded structures has been impossible. Here we report a transgenic method in Caenorhabditis elegans that allows direct live imaging of specific heparan sulfate modification patterns. This experimental approach reveals a dynamic and cell-specific heparan sulfate landscape and could in principle be adapted to visualize and analyze any extracellular molecule in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.