ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2012
Clinical observation of immunity in patients with secondary infection from severe acute pancreatitis.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Effect of regional arterial infusion combined with early enteral nutrition on severe acute pancreatitis.The Journal of international medical research · 2019Trial
- From pancreas to lungs: The role of immune cells in severe acute pancreatitis and acute lung injury.Immunity, inflammation and disease · 2024Review
- Intestinal Mucosal Immune Barrier: A Powerful Firewall Against Severe Acute Pancreatitis-Associated Acute Lung Injury via the Gut-Lung Axis.Journal of inflammation research · 2024Review
- The impact of multi-drug resistant Pseudomonas aeruginosa infections on acute pancreatitis patients.BMC infectious diseases · 2023Article
- Innate Lymphoid Cells: Emerging Players in Pancreatic Disease.International journal of molecular sciences · 2022Review
- Role of Interleukin-17 in Acute Pancreatitis.Frontiers in immunology · 2021Review
- T Lymphocytes: A Promising Immunotherapeutic Target for Pancreatitis and Pancreatic Cancer?Frontiers in oncology · 2020Review
- Circulating Lymphocyte Subsets Induce Secondary Infection in Acute Pancreatitis.Frontiers in cellular and infection microbiology · 2020Review
- Timing, distribution, and microbiology of infectious complications after necrotizing pancreatitis.World journal of gastroenterology · 2019Article
- Association of Systemic Inflammatory and Anti-inflammatory Responses with Adverse Outcomes in Acute Pancreatitis: Preliminary Results of an Ongoing Study.Digestive diseases and sciences · 2017Observational
- The diffuse reduction in spleen density: an indicator of severe acute pancreatitis?Bioscience reports · 2017Article
- Article
- Relationship between the degree of severe acute pancreatitis and patient immunity.Surgery today · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo observe immune system changes in patients with secondary infection from severe acute pancreatitis (SAP).
methodsSeventy-nine patients were recruited. The percentages of CD4+, CD8+, natural killer (NK), HLA-DR+ cells and B lymphocytes, and the CD4+/CD8+ ratio, were determined. In addition, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), and interleukin-4 (IL-4) serum levels were determined on days 1, 7, 14, and 28.
resultsFifteen patients had a secondary infection. The immune response of the infected group was quite different from the non-infected group, with a higher percentage of CD4+ and HLA-DR+ cells on days 1, 7, 14 and 28, a higher percentage of CD8+ and NK cells on days 14 and 28, a reduced CD4+/CD8+ ratio, and a reduction in B lymphocytes. The cytokine levels in the infected group were different from the non-infected group, with a rise in TNF-α and IL-6 through the first 2 weeks, but dropping at 1 month. IL-10 and IL-4 increased initially, but then dropped over the next 3 weeks.
conclusionsAn early excessive immune response followed by a subsequent immune deficiency is closely related to secondary SAP infection.
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