ArticleRetina (Philadelphia, Pa.)2012
Plus disease in retinopathy of prematurity: diagnostic impact of field of view.
Article in Retina (Philadelphia, Pa.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 citations in OpenAlex.
- Impact of image enhancement on grading agreement of plus disease features in retinopathy of prematurity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Does field of view matter? Assessing its impact on Plus disease diagnosis in retinopathy of prematurity.International journal of retina and vitreous · 2025Article
- Establishing an objective quantitative method for assessing the severity of plus disease in retinopathy of prematurity.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- The Role of Telemedicine to Alleviate an Increasingly Burdened Healthcare System: Retinopathy of Prematurity.Ophthalmology and therapy · 2020Review
- Auto-Processed Retinal Vessel Shadow View Images From Bedside Optical Coherence Tomography to Evaluate Plus Disease in Retinopathy of Prematurity.Translational vision science & technology · 2020Article
- Plus Disease in Retinopathy of Prematurity: Convolutional Neural Network Performance Using a Combined Neural Network and Feature Extraction Approach.Translational vision science & technology · 2020Article
- Accuracy and Reliability of Eye-Based vs Quadrant-Based Diagnosis of Plus Disease in Retinopathy of Prematurity.JAMA ophthalmology · 2018Article
- Single grading vs double grading with adjudication in the telemedicine approaches to evaluating acute-phase retinopathy of prematurity (e-ROP) study.Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2018Article
- Posterior Pole Vascular Changes Before Treatment of Retinopathy of Prematurity.JAMA ophthalmology · 2017Article
- Plus Disease in Retinopathy of Prematurity: Diagnostic Trends in 2016 Versus 2007.American journal of ophthalmology · 2017Article
- Influence of Computer-Generated Mosaic Photographs on Retinopathy of Prematurity Diagnosis and Management.JAMA ophthalmology · 2016Article
- Plus Disease in Retinopathy of Prematurity: A Continuous Spectrum of Vascular Abnormality as a Basis of Diagnostic Variability.Ophthalmology · 2016Article
- Plus Disease in Retinopathy of Prematurity: Improving Diagnosis by Ranking Disease Severity and Using Quantitative Image Analysis.Ophthalmology · 2016Article
- Diagnostic Discrepancies in Retinopathy of Prematurity Classification.Ophthalmology · 2016Observational
- Expert Diagnosis of Plus Disease in Retinopathy of Prematurity From Computer-Based Image Analysis.JAMA ophthalmology · 2016Article
- Computer-Based Image Analysis for Plus Disease Diagnosis in Retinopathy of Prematurity: Performance of the "i-ROP" System and Image Features Associated With Expert Diagnosis.Translational vision science & technology · 2015Article
- Dealing with inter-expert variability in retinopathy of prematurity: A machine learning approach.Computer methods and programs in biomedicine · 2015Article
- Plus disease diagnosis in retinopathy of prematurity: vascular tortuosity as a function of distance from optic disk.Retina (Philadelphia, Pa.) · 2013Article
- Plus disease in retinopathy of prematurity: qualitative analysis of diagnostic process by experts.JAMA ophthalmology · 2013Article
- Image analysis for retinopathy of prematurity: where are we headed?Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
purposeTo examine the impact of retinal field of view and magnification on interexpert reliability of plus disease diagnosis in retinopathy of prematurity.
methodsFifteen wide-angle images from infants with retinopathy of prematurity were cropped and adjusted in magnification to create 2 additional image categories: medium angle (40°-50°) and narrow angle (20°-30°). These 45 images were uploaded to a Web-based system and interpreted independently by 13 experts of retinopathy of prematurity using a 3-level (plus, preplus, neither) and 2-level (plus, not plus) classification. Absolute agreement and kappa statistics were calculated to compare interexpert reliability.
resultsIn the 3-level classification, ≥ 70% experts agreed on the same diagnosis in 8 of the 15 wide-angle images (53%), but only in 3 of the 15 medium-angle (20%) and 3 of the 15 narrow-angle (20%) images. In the 2-level classification, ≥ 80% experts agreed on the same diagnosis in 11 of the 15 wide-angle images (73%), but only in 9 of the 15 medium-angle (60%) and 3 of the 15 narrow-angle (20%) images. Mean kappa of each expert compared with all other experts was 0.40 to 0.59 in 8 of 13 experts (62%) using wide-angle images, was 0 to 0.19 in 7 of 13 experts (54%) using medium-angle images, and was 0.20 to 0.39 in 9 of 13 experts (69%) using narrow-angle images.
conclusionInterexpert agreement in plus disease diagnosis in wide-angle images is higher than from medium-angle and narrow-angle images. Plus disease is defined using a narrow-angle standard published photograph, yet this study suggests that peripheral findings also contribute to diagnosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.