ReviewNeuroscience bulletin2012
Population coding of somatic sensations.
Review in Neuroscience bulletin, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Intrinsic circadian organization of the spinal cord and dorsal root ganglia.Pain reports · 2026Article
- Recent Advances in Unraveling the Mechanisms of Pain and Itch: The Third Special Issue.Neuroscience bulletin · 2025Article
- Article
- Defective branched-chain amino acid catabolism in dorsal root ganglia contributes to mechanical pain.EMBO reports · 2023Article
- A DRG genetic toolkit reveals molecular, morphological, and functional diversity of somatosensory neuron subtypes.bioRxiv : the preprint server for biology · 2023Article
- Multiplexed Representation of Itch and Pain and Their Interaction in the Primary Somatosensory Cortex.Experimental neurobiology · 2022Article
- Neuronal pentraxin 2 is required for facilitating excitatory synaptic inputs onto spinal neurons involved in pruriceptive transmission in a model of chronic itch.Nature communications · 2022Article
- Modality-Specific Modulation of Temperature Representations in the Spinal Cord after Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Single cell transcriptomics of primate sensory neurons identifies cell types associated with chronic pain.Nature communications · 2021Article
- Neural Design Principles for Subjective Experience: Implications for Insects.Frontiers in behavioral neuroscience · 2021Article
- Novel Analgesics with Peripheral Targets.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020Review
- Transcriptional Control of the Development of Myelinated Mechano-nociceptors.Neuroscience bulletin · 2020Article
- Getting in Touch with Mechanical Pain Mechanisms.Trends in neurosciences · 2020Review
- Spinal cord projection neurons: a superficial, and also deep, analysis.Current opinion in physiology · 2019Article
- Probing the coding logic of thermosensation using spinal cord calcium imaging.Experimental neurology · 2019Review
- Oral thermosensing by murine trigeminal neurons: modulation by capsaicin, menthol and mustard oil.The Journal of physiology · 2019Article
- Organization of the Thermal Grill Illusion by Spinal Segments.Annals of neurology · 2018Article
- Cooling Relief of Acute and Chronic Itch Requires TRPM8 Channels and Neurons.The Journal of investigative dermatology · 2018Article
- Neuronal atlas of the dorsal horn defines its architecture and links sensory input to transcriptional cell types.Nature neuroscience · 2018Article
- Spinal Circuits for Touch, Pain, and Itch.Annual review of physiology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The somatic sensory system includes a variety of sensory modalities, such as touch, pain, itch, and temperature sensitivity. The coding of these modalities appears to be best explained by the population-coding theory, which is composed of the following features. First, an individual somatic sensory afferent is connected with a specific neural circuit or network (for simplicity, a sensory-labeled line), whose isolated activation is sufficient to generate one specific sensation under normal conditions. Second, labeled lines are interconnected through local excitatory and inhibitory interneurons. As a result, activation of one labeled line could modulate, or provide gate control of, another labeled line. Third, most sensory fibers are polymodal, such that a given stimulus placed onto the skin often activates two or multiple sensory-labeled lines; crosstalk among them is needed to generate one dominant sensation. Fourth and under pathological conditions, a disruption of the antagonistic interaction among labeled lines could open normally masked neuronal pathways, and allow a given sensory stimulus to evoke a new sensation, such as pain evoked by innocuous mechanical or thermal stimuli and itch evoked by painful stimuli. As a result of this, some sensory fibers operate along distinct labeled lines under normal versus pathological conditions. Thus, a better understanding of the neural network underlying labeled line crosstalk may provide new strategies to treat chronic pain and itch.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.