Evidence map›Paper›PMID 22465856›Full record

ReviewBiochimica et biophysica acta2012

Insights into the mechanism of electron transfer and sodium translocation of the Na(+)-pumping NADH:quinone oxidoreductase.

Oscar Juárez, Blanca Barquera

Open access · greenAbstract readReview
In one paragraph

Review in Biochimica et biophysica acta, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. Conformational Dynamics of NaJournal of chemical information and modeling · 2026
    Article
  3. The redox driven NaNature communications · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. NQR as a target for new antibiotics.Frontiers in microbiology · 2025
    Review
  11. Article
  12. The respiratory chain ofFrontiers in microbiology · 2024
    Article
  13. Article
  14. Article
  15. Cryo-EM structures of NaNature communications · 2022
    Article
  16. The side chain of ubiquinone plays a critical role in NaBiochimica et biophysica acta. Bioenergetics · 2022
    Article
  17. Article
  18. Article
  19. Inhibitors of a NaThe Journal of biological chemistry · 2020
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Oscar JuárezDepartment of Biology, Rensselaer Polytechnic Institute, Troy, NY, USA. juareo@rpi.edu
Blanca Barquera
Rensselaer Polytechnic Institute · US

Funding

A new paradigm of respiration in the human gut BacteroidesR01AI132580 · NIAID · RENSSELAER POLYTECHNIC INSTITUTE · PI BARQUERA, BLANCA, COMSTOCK, LAURIE E · 2017 to 2020
$2.4M
NIAID NIH HHS R01 AI132580NIGMS NIH HHS GM060036
6 · The paper itself

Abstract

Na(+)-NQR is a unique energy-transducing complex, widely distributed among marine and pathogenic bacteria. It converts the energy from the oxidation of NADH and the reduction of quinone into an electrochemical Na(+)-gradient that can provide energy for the cell. Na(+)-NQR is not homologous to any other respiratory protein but is closely related to the RNF complex. In this review we propose that sodium pumping in Na(+)-NQR is coupled to the redox reactions by a novel mechanism, which operates at multiple sites, is indirect and mediated by conformational changes of the protein. This article is part of a Special Issue entitled: 17th European Bioenergetics Conference (EBEC 2012).

Indexed as

NADH, NADPH OxidoreductasesNADPSodium-Potassium-Exchanging ATPaseCatalytic DomainOxidation-ReductionNADH, NADPH OxidoreductasesNADPSodium-Potassium-Exchanging ATPase

Identifiers

PMID22465856
PMCPMC8172247
OpenAlexW2092035009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.