ArticleBone2012
Different effects of age, adiposity and physical activity on the risk of ankle, wrist and hip fractures in postmenopausal women.
Article in Bone, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Pooled it
- Pooled it
- The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial.Obesity (Silver Spring, Md.) · 2023Trial
- Association of physical activity with fracture: a prospective cohort study of 387,307 Chinese participants.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Associations of Accelerometer-Measured Physical Activity and Sedentary Behavior With Incident Clinical Osteoporotic Fractures Among Older Women: The Objective Physical Activity and Cardiovascular Health Study.Journal of aging and physical activity · 2026Article
- Article
- High physical activity is associated with greater cortical bone size, better physical function, and with lower risk of incident fractures independently of clinical risk factors in older women from the SUPERB study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Causal relationships between height and weight with distal tibia microarchitecture and geometry in adult female twin pairs.JBMR plus · 2024Article
- Risk of Bone Fracture on Vegetarian and Vegan Diets.Current nutrition reports · 2024Review
- Association between obesity and fracture risk in Chinese women above 50 years of age: a prospective cohort study.BMC public health · 2024Article
- Implications of obesity in patients with foot and ankle pathology.World journal of orthopedics · 2023Review
- Relationships between Obesity and Incidence of Fractures in a Middle-Aged Population: A Study from the CARTaGENE Cohort.JBMR plus · 2023Article
- Risk of hip fracture in meat-eaters, pescatarians, and vegetarians: results from the UK Women's Cohort Study.BMC medicine · 2022Article
- Distribution of Fracture Sites in Postmenopausal Overweight and Obese Women: The FRISBEE Study.Calcified tissue international · 2022Article
- Gender differences in modifiable risk factors for hip fracture: 10-year follow-up of a prospective study of 0.5 million Chinese adults.Journal of internal medicine · 2022Article
- Changes in physical activity levels and relationship to balance performance, gait speed, and self-rated health in older Swedish women: a longitudinal study.Aging clinical and experimental research · 2022Article
- Vegetarian and vegan diets and risks of total and site-specific fractures: results from the prospective EPIC-Oxford study.BMC medicine · 2020Article
- The Associations Between Seven Different Types of Physical Activity and the Incidence of Fracture at Seven Sites in Healthy Postmenopausal UK Women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020Article
- Does the Prediction Accuracy of Osteoporotic Fractures by BMD and Clinical Risk Factors Vary With Fracture Site?JBMR plus · 2019Article
- Association of Physical Activity and Fracture Risk Among Postmenopausal Women.JAMA network open · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
While increasing age, decreasing body mass index (BMI), and physical inactivity are known to increase hip fracture risk, whether these factors have similar effects on other common fractures is not well established. We used prospectively-collected data from a large cohort to examine the role of these factors on the risk of incident ankle, wrist and hip fractures in postmenopausal women. 1,155,304 postmenopausal participants in the Million Women Study with a mean age of 56.0 (SD 4.8) years, provided information about lifestyle, anthropometric, and reproductive factors at recruitment in 1996-2001. All participants were linked to National Health Service cause-specific hospital records for day-case or overnight admissions. During follow-up for an average of 8.3 years per woman, 6807 women had an incident ankle fracture, 9733 an incident wrist fracture, and 5267 an incident hip fracture. Adjusted absolute and relative risks (RRs) for incident ankle, wrist, and hip fractures were calculated using Cox regression models. Age-specific rates for wrist and hip fractures increased sharply with age, whereas rates for ankle fracture did not. Cumulative absolute risks from ages 50 to 84 years per 100 women were 2.5 (95%CI 2.2-2.8) for ankle fracture, 5.0 (95%CI 4.4-5.5) for wrist fracture, and 6.2 (95%CI 5.5-7.0) for hip fracture. Compared with lean women (BMI<20 kg/m(2)), obese women (BMI≥30 kg/m(2)) had a three-fold increased risk of ankle fracture (RR=3.07; 95%CI 2.53-3.74), but a substantially reduced risk of wrist fracture and especially of hip fracture (RR=0.57; 0.51-0.64 and 0.23; 0.21-0.27, respectively). Physical activity was associated with a reduced risk of hip fracture but was not associated with ankle or wrist fracture risk. Ankle, wrist and hip fractures are extremely common in postmenopausal women, but the associations with age, adiposity, and physical activity differ substantially between the three fracture sites.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.