Evidence map›Paper›PMID 22465841›Full record

ArticleNeuroImage2012

Evidence for coordinated functional activity within the extended amygdala of non-human and human primates.

Jonathan A Oler, Rasmus M Birn, Rémi Patriat, Andrew S Fox, Steven E Shelton, Cory A Burghy, Diane E Stodola, Marilyn J Essex, Richard J Davidson, Ned H Kalin

Open access · greenAbstract read
In one paragraph

Article in NeuroImage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Jonathan A OlerDepartment of Psychiatry, University of Wisconsin-Madison, Madison, WI 53719, USA. oler@wisc.edu
Rasmus M Birn
Rémi Patriat
Andrew S Fox
Steven E Shelton
Cory A Burghy
Diane E Stodola
Marilyn J Essex
Richard J Davidson
Ned H Kalin
University of Wisconsin–Madison · US

Funding

WISCONSIN CENTER ON MENTAL RETARDATION: CORE SUPPORTP30HD003352 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI SVAREN, JOHN P · 1985 to 2015
$25.2M
DEVELOPMENT AND REGULATION OF EMOTION IN PRIMATESR01MH046729 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Ned H Kalin · 1990 to 2026
$15.3M
Brain Mechanisms Mediating Genetic Risk For Anxiety And DepressionR01MH081884 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI Ned H Kalin · 2008 to 2026
$14.8M
STRESS EXPOSURE, HPA ACTIVITY AND RISK FOR ADOLESCENT INTERNALIZING DISORDERSP50MH084051 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI DAVIDSON, RICHARD J · 2008 to 2012
$9.6M
NICHD NIH HHS P30 HD003352NICHD NIH HHS P30-HD03352NIMH NIH HHS P50 MH084051NIMH NIH HHS P50-MH084051NIMH NIH HHS R01 MH046729NIMH NIH HHS R01-MH046729NIMH NIH HHS R01 MH081884NIMH NIH HHS R01-MH081884
6 · The paper itself

Abstract

Neuroanatomists posit that the central nucleus of the amygdala (Ce) and bed nucleus of the stria terminalis (BST) comprise two major nodes of a macrostructural forebrain entity termed the extended amygdala. The extended amygdala is thought to play a critical role in adaptive motivational behavior and is implicated in the pathophysiology of maladaptive fear and anxiety. Resting functional connectivity of the Ce was examined in 107 young anesthetized rhesus monkeys and 105 young humans using standard resting-state functional magnetic resonance imaging (fMRI) methods to assess temporal correlations across the brain. The data expand the neuroanatomical concept of the extended amygdala by finding, in both species, highly significant functional coupling between the Ce and the BST. These results support the use of in vivo functional imaging methods in nonhuman and human primates to probe the functional anatomy of major brain networks such as the extended amygdala.

Indexed as

AdolescentAmygdalaAnimalsAnxietyChildFearFemaleHumansImage Processing, Computer-AssistedMacaca mulattaMagnetic Resonance ImagingMaleNeural Pathways

Identifiers

PMID22465841
PMCPMC3376204
OpenAlexW2153220740

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.