Evidence map›Paper›PMID 22465511›Full record

ReviewBlood cells, molecules & diseases2012

Refined views of multi-protein complexes in the erythrocyte membrane.

T J Mankelow, T J Satchwell, N M Burton

Abstract readReview
In one paragraph

Review in Blood cells, molecules & diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Role of channels in the ObioRxiv : the preprint server for biology · 2025
    Article
  3. Host-pathogen interactions involved in erythrocyte invasion byFrontiers in cellular and infection microbiology · 2025
    Article
  4. Article
  5. Article
  6. Chloride Gradient Is Involved in Ammonium Influx in Human Erythrocytes.International journal of molecular sciences · 2024
    Article
  7. Review
  8. Architecture of the human erythrocyte ankyrin-1 complex.Nature structural & molecular biology · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. The Cellular and Molecular Interaction Between Erythrocytes andFrontiers in cellular and infection microbiology · 2022
    Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Sickle Cell Trait Modulates the Proteome and Phosphoproteome ofFrontiers in cellular and infection microbiology · 2021
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

T J MankelowBristol Institute for Transfusion Sciences, N.H.S. Blood & Transplant, UK.
T J Satchwell
N M Burton
University of Bristol · GBNHS Blood and Transplant · GB

Funding

Department of Health RP-PG-0310-1004Wellcome Trust 094277
6 · The paper itself

Abstract

The erythrocyte membrane has been extensively studied, both as a model membrane system and to investigate its role in gas exchange and transport. Much is now known about the protein components of the membrane, how they are organised into large multi-protein complexes and how they interact with each other within these complexes. Many links between the membrane and the cytoskeleton have also been delineated and have been demonstrated to be crucial for maintaining the deformability and integrity of the erythrocyte. In this study we have refined previous, highly speculative molecular models of these complexes by including the available data pertaining to known protein-protein interactions. While the refined models remain highly speculative, they provide an evolving framework for visualisation of these important cellular structures at the atomic level.

Indexed as

Models, BiologicalAnimalsBiological TransportErythrocyte MembraneHumansMembrane ProteinsMultiprotein ComplexesMembrane ProteinsMultiprotein Complexes

Identifiers

PMID22465511
PMCPMC4443426
OpenAlexW1994520287

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.