ArticleAmerican journal of surgery2012
The age of transfused blood predicts hematocrit response among critically ill surgical patients.
Article in American journal of surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Relationship between red cell storage duration and outcomes in adults receiving red cell transfusions: a systematic review.Critical care (London, England) · 2013Pooled it
- Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019Review
- Microparticles formed during storage of red blood cell units support thrombin generation.The journal of trauma and acute care surgery · 2018Article
- Blood Quality Diagnostic Device Detects Storage Differences Between Donors.IEEE transactions on biomedical circuits and systems · 2017Article
- Sexual dimorphism in hematocrit response following red blood cell transfusion of critically ill surgical patients.ISRN hematology · 2012Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundIn vitro data suggest that erythrocytes undergo storage time-dependent degradation, eventuating in hemolysis. We hypothesize that transfusion of old blood, as compared with newer blood, results in a smaller increment in hematocrit.
methodsWe performed an analysis of packed red blood cell transfusions administered in the surgical intensive care unit. Age of blood was analyzed as continuous, dichotomized at 14 days (old vs new), and grouped by weeks old.
resultsA total of 136 U of packed red blood cells were given to 52 patients; 110 (80.9%) were 14 days old or more. A linear, inverse correlation was observed between the age of blood and the increment in hematocrit (r(2) = -.18, P = .04). The increment in hematocrit was greater after transfusion of new as compared with old blood (5.6% vs 3.5%, respectively; P = .005). A linear relationship also was observed between the age of transfused blood in weeks and the increment in hematocrit (P = .02).
conclusionsThere is an inverse relationship between the age of blood and the increment in hematocrit. The age of blood should be considered before transfusion of surgical patients with intensive care unit anemia.
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