ArticleNeuroscience letters2012
Elucidating the role of 5-HT(1A) and 5-HT(7) receptors on 8-OH-DPAT-induced behavioral recovery after experimental traumatic brain injury.
Article in Neuroscience letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Delayed-and-abbreviated environmental enrichment after traumatic brain injury confers neurobehavioral benefits similar to immediate-and-continuous exposure.Brain research · 2025Article
- Strain in the Midbrain: Impact of Traumatic Brain Injury on the Central Serotonin System.Brain sciences · 2024Review
- Altered Serotonin 2A (5-HTFrontiers in pharmacology · 2022Article
- A combined therapeutic regimen of citalopram and environmental enrichment ameliorates attentional set-shifting performance after brain trauma.European journal of pharmacology · 2021Article
- Environmental enrichment and amantadine confer individual but nonadditive enhancements in motor and spatial learning after controlled cortical impact injury.Brain research · 2019Article
- Spontaneous recovery of traumatic brain injury-induced functional deficits is not hindered by daily administration of lorazepam.Behavioural brain research · 2018Article
- Abbreviated environmental enrichment confers neurobehavioral, cognitive, and histological benefits in brain-injured female rats.Experimental neurology · 2016Article
- 5-hydroxytryptamine1A (5-HT1A) receptor agonists: A decade of empirical evidence supports their use as an efficacious therapeutic strategy for brain trauma.Brain research · 2016Review
- Found in translation: Understanding the biology and behavior of experimental traumatic brain injury.Neuroscience and biobehavioral reviews · 2015Review
- Targeting α7 nicotinic acetylcholine receptors: a future potential for neuroprotection from traumatic brain injury.Neural regeneration research · 2015Article
- A combined therapeutic regimen of buspirone and environmental enrichment is more efficacious than either alone in enhancing spatial learning in brain-injured pediatric rats.Journal of neurotrauma · 2014Article
- Old dog, new tricks: the attentional set-shifting test as a novel cognitive behavioral task after controlled cortical impact injury.Journal of neurotrauma · 2014Article
- Environmental enrichment promotes robust functional and histological benefits in female rats after controlled cortical impact injury.Experimental neurology · 2013Article
- Donepezil is ineffective in promoting motor and cognitive benefits after controlled cortical impact injury in male rats.Journal of neurotrauma · 2013Article
- 8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury.Neural regeneration research · 2013Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
8-OH-DPAT is a 5-HT(1A/7) receptor agonist that enhances behavioral recovery after traumatic brain injury (TBI). This study is a first attempt to decipher whether the benefits induced by 8-OH-DPAT after TBI are mediated by 5-HT(1A) or 5-HT(7) receptors. A single i.p. injection of 8-OH-DPAT (0.5 mg/kg) alone or co-administered with either the 5-HT(1A) or 5-HT(7) receptor antagonists WAY 100635 (0.5 mg/kg) or SB 269970 HCl (2.0 mg/kg), respectively, or vehicle control (1.0 mL/kg) was given 15 min after cortical impact or sham injury. Function was assessed by established motor and cognitive tests. No difference in motor performance was observed among the TBI groups. Spatial acquisition was enhanced, relative to vehicle controls, by 8-OH-DPAT alone and when co-administered with WAY 100635, but not when combined with SB 269970 HCl. These data imply that 5-HT(1A) receptor antagonism does not abate the 8-OH-DPAT-induced cognitive benefits, but 5-HT(7) receptor antagonism does, which suggests that the 8-OH-DPAT-induced benefits in this single administration paradigm may be mediated more by 5-HT(7) versus 5-HT(1A) receptors. Evaluation of a specific 5-HT(7) receptor agonist will further elucidate the contribution of 5-HT(1A) and 5-HT(7) receptors on behavioral recovery conferred by acute 8-OH-DPAT treatment after TBI.
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Registered trials
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