Evidence map›Paper›PMID 22465255›Full record

ArticleJournal of virological methods2012

Performance of the Luminex xTAG Respiratory Viral Panel Fast in a clinical laboratory setting.

Pia Jokela, Heli Piiparinen, Laura Mannonen, Eeva Auvinen, Maija Lappalainen

Open access · greenAbstract readComparative StudyEvaluation Study
In one paragraph

Article in Journal of virological methods, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Specific probiotics and virological findings in symptomatic conscripts attending military service in Finland.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2014
    Trial
  4. Article
  5. Article
  6. Article
  7. Simultaneous Detection of Nine Key Bacterial Respiratory Pathogens Using Luminex xTAGInternational journal of environmental research and public health · 2017
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Pathology Consultation on Influenza Diagnostics.American journal of clinical pathology · 2016
    Review
  14. Article
  15. Article
  16. Simultaneous Detection of Five Pathogens from Cerebrospinal Fluid Specimens Using Luminex Technology.International journal of environmental research and public health · 2016
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Pia JokelaDepartment of Virology, Haartman Institute, University of Helsinki, FIN-00014 Helsinki, Finland. pia.jokela@helsinki.fi
Heli Piiparinen
Laura Mannonen
Eeva Auvinen
Maija Lappalainen
Helsinki University Hospital · FIUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the study was to develop a real-time RT-PCR for the detection of enteroviruses (EVs) and rhinoviruses (RVs) and to assess the performance of the xTAG RVP Fast assay in comparison to a direct fluorescent assay (DFA), a real-time RT-PCR assay for the detection of respiratory syncytial virus (RSV) and human metapneumovirus (hMPV), and the EV/RV RT-PCR assay developed in this study. The performance of the RVP Fast assay was assessed in the analysis of 373 nasopharyngeal samples. For the viruses of the DFA panel, detection rates of 27.6% and 23.8% were obtained by RVP and DFA, respectively, in analysis of a set of 297 samples collected in 2009-2010. These results show statistically significant superiority of the RVP Fast assay (P=0.049). For RSV, hMPV, EV, and RV, detection rates of 48.0% and 45.2% were achieved by RVP and RT-PCR, respectively. For individual targets, increased detection of EV/RV (P=0.043) and decreased detection of influenza A virus (P=0.004) by RVP in comparison to real-time RT-PCR was observed. The results of the present study imply the need to adjust the InfA component of the RVP Fast assay to also cover the InfA(H1N1) 2009 virus.

Indexed as

Clinical Laboratory TechniquesEnterovirusHumansMolecular Diagnostic TechniquesNasopharynxReal-Time Polymerase Chain ReactionRespiratory Tract InfectionsReverse Transcriptase Polymerase Chain ReactionRhinovirusSensitivity and SpecificityVirologyVirus Diseases

Identifiers

PMID22465255
PMCPMC7119588
OpenAlexW2045507941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.