ArticleJournal of affective disorders2012
Pediatric bipolar disorder and ADHD: family history comparison in the LAMS clinical sample.
Article in Journal of affective disorders, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Machine learning reveals a multimodal, transdiagnostic signature of emotion dysregulation vulnerability across patients, offspring, and controls.Molecular psychiatry · 2026Article
- Inflammation and emotion regulation: a narrative review of evidence and mechanisms in emotion dysregulation disorders.Neuronal signaling · 2023Review
- Review
- Development of bipolar disorder and other comorbidity among youth with attention-deficit/hyperactivity disorder.Journal of child psychology and psychiatry, and allied disciplines · 2020Article
- Parenting Stress Among Caregivers of Children With Bipolar Spectrum Disorders.Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53 · 2018Article
- Understanding Early Age of Onset: a Review of the Last 5 Years.Current psychiatry reports · 2016Review
- Cognitive flexibility and performance in children and adolescents with threshold and sub-threshold bipolar disorder.European child & adolescent psychiatry · 2016Article
- Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up.World journal of psychiatry · 2015Article
- White matter structure in youth with behavioral and emotional dysregulation disorders: a probabilistic tractographic study.JAMA psychiatry · 2015Article
- Decreased amygdala-insula resting state connectivity in behaviorally and emotionally dysregulated youth.Psychiatry research · 2015Article
- Comparison of clinical characteristics of bipolar and depressive disorders in Korean clinical sample of youth: a retrospective chart review.European child & adolescent psychiatry · 2014Article
- Parsing dimensional vs diagnostic category-related patterns of reward circuitry function in behaviorally and emotionally dysregulated youth in the Longitudinal Assessment of Manic Symptoms study.JAMA psychiatry · 2014Article
- How does a Developmental Perspective inform us about the early Natural History of Bipolar Disorder?Journal of the Canadian Academy of Child and Adolescent Psychiatry = Journal de l'Academie canadienne de psychiatrie de l'enfant et de l'adolescent · 2013Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundTransgenerational association of bipolar spectrum disorder (BPSD) and attention deficit/hyperactivity disorder (ADHD) has been reported, but inconclusively.
methodChildren ages 6-12 were systematically recruited at first outpatient visit at 9 clinics at four universities and reliably diagnosed; 621 had elevated symptoms of mania (>12 on the Parent General Behavior Inventory 10-Item Mania Scale); 86 had scores below 12. We analyzed baseline data to test a familial association hypothesis: compared to children with neither BPSD nor ADHD, those with either BPSD or ADHD would have parents with higher rates of both bipolar and ADHD symptoms, and parents of comorbid children would have even higher rates of both.
resultsOf 707 children, 421 had ADHD without BPSD, 45 BPSD without ADHD, 117 comorbid ADHD+BPSD, and 124 neither. The rate of parental manic symptoms was similar for the comorbid and BPSD-alone groups, significantly greater than for ADHD alone and "neither" groups, which had similar rates. ADHD symptoms in parents of children with BPSD alone were significantly less frequent than in parents of children with ADHD (alone or comorbid), and no greater than for children with neither diagnosis. Family history of manic symptoms, but not ADHD symptoms, was associated with parent-rated child manic-symptom severity over and above child diagnosis. LIMITATIONS: The sample was not epidemiologic, parent symptoms were based on family history questions, and alpha was 0.05 despite multiple tests.
conclusionsThese results do not support familial linkage of BPSD and ADHD; they are compatible with heritability of each disorder separately with coincidental overlap.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.