ArticleEJNMMI research2012
High resolution tumor targeting in living mice by means of multispectral optoacoustic tomography.
Article in EJNMMI research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Assessment of Breast Tumors Using Multispectral Optoacoustic Tomography in a Surgical Setting.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025Trial
- Photoacoustic Imaging in Biomedicine and Life Sciences.Life (Basel, Switzerland) · 2022Review
- Multi-Aspect Optoacoustic Imaging of Breast Tumors under Chemotherapy with Exogenous and Endogenous Contrasts: Focus on Apoptosis and Hypoxia.Biomedicines · 2021Article
- In vivo tracking of orally-administered particles within the gastrointestinal tract of murine models using multispectral optoacoustic tomography.Photoacoustics · 2019Article
- Statistical independence in nonlinear model-based inversion for quantitative photoacoustic tomography.Biomedical optics express · 2017Article
- Functional optoacoustic neuro-tomography for scalable whole-brain monitoring of calcium indicators.Light, science & applications · 2016Article
- Simultaneous visualization of tumour oxygenation, neovascularization and contrast agent perfusion by real-time three-dimensional optoacoustic tomography.European radiology · 2016Article
- Tumor specific liposomes improve detection of pancreatic adenocarcinoma in vivo using optoacoustic tomography.Journal of nanobiotechnology · 2015Article
- Targeting Acidity in Pancreatic Adenocarcinoma: Multispectral Optoacoustic Tomography Detects pH-Low Insertion Peptide Probes In Vivo.Clinical cancer research : an official journal of the American Association for Cancer Research · 2015Article
- Measures of kidney function by minimally invasive techniques correlate with histological glomerular damage in SCID mice with adriamycin-induced nephropathy.Scientific reports · 2015Article
- Molecular photoacoustic imaging of breast cancer using an actively targeted conjugated polymer.International journal of nanomedicine · 2015Article
- Orthotopic pancreatic tumors detected by optoacoustic tomography using Syndecan-1.The Journal of surgical research · 2015Article
- Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography.Cancer research · 2014Article
- Multifunctional photosensitizer-based contrast agents for photoacoustic imaging.Scientific reports · 2014Article
- Functional optoacoustic human angiography with handheld video rate three dimensional scanner.Photoacoustics · 2013Article
- Optoacoustic imaging and tomography: reconstruction approaches and outstanding challenges in image performance and quantification.Sensors (Basel, Switzerland) · 2013Article
- Measuring response to therapy by near-infrared imaging of tumors using a phosphatidylserine-targeting antibody fragment.Molecular imaging · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundTumor targeting is of high clinical and biological relevance, and major efforts have been made to develop molecular imaging technologies for visualization of the disease markers in tissue. Of particular interest is apoptosis which has a profound role within tumor development and has significant effect on cancer malignancy.
methodsHerein, we report on targeting of phosphatidylserine-exposing cells within live tumor allograft models using a synthetic near infrared zinc(II)-dipicolylamine probe. Visualization of the probe biodistribution is performed with whole body multispectral optoacoustic tomography (MSOT) system and subsequently compared to results attained by planar and tomographic fluorescence imaging systems.
resultsCompared to whole body optical visualization methods, MSOT attains remarkably better imaging capacity by delivering high-resolution scans of both disease morphology and molecular function in real time. Enhanced resolution of MSOT clearly showed that the probe mainly localizes in the vessels surrounding the tumor, suggesting that its tumor selectivity is gained by targeting the phosphatidylserine exposed on the surface of tumor vessels.
conclusionsThe current study demonstrates the high potential of MSOT to broadly impact the fields of tumor diagnostics and preclinical drug development.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.