ArticleImmunity2012
Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila.
Article in Immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- Purine and pyrimidine-based bacterial cyclic dinucleotides egress the phagosome and activate the innate immune sensor STING.Immunity · 2026Article
- A genetic screen in Drosophila reveals the role of fucosylation in host susceptibility to Candida infection.Disease models & mechanisms · 2022Article
- Bacterial recognition by PGRP-SA and downstream signalling by Toll/DIF sustain commensal gut bacteria in Drosophila.PLoS genetics · 2022Article
- Evolution of Toll, Spatzle and MyD88 in insects: the problem of the Diptera bias.BMC genomics · 2021Article
- A reaction-diffusion network model predicts a dual role of Cactus/IκB to regulate Dorsal/NFκB nuclear translocation in Drosophila.PLoS computational biology · 2021Article
- Bacterial Engulfment Mechanism Is Strongly Conserved in Evolution Between Earthworm and Human Immune Cells.Frontiers in immunology · 2021Article
- A survey of TIR domain sequence and structure divergence.Immunogenetics · 2020Article
- Lipids that directly regulate innate immune signal transduction.Innate immunity · 2020Review
- Article
- The Fly Way of Antiviral Resistance and Disease Tolerance.Advances in immunology · 2018Review
- A novel function for the IκB inhibitor Cactus in promoting Dorsal nuclear localization and activity in theDevelopment (Cambridge, England) · 2017Article
- AThe EMBO journal · 2017Article
- Early innate immune responses to bacterial LPS.Current opinion in immunology · 2017Review
- Microbe-inducible trafficking pathways that control Toll-like receptor signaling.Traffic (Copenhagen, Denmark) · 2017Review
- The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors.Nature immunology · 2016Article
- R.I.P. dead bacteria, you will not be attacked.Nature immunology · 2016Article
- Alcohol resistance in Drosophila is modulated by the Toll innate immune pathway.Genes, brain, and behavior · 2016Article
- Hm-MyD88 and Hm-SARM: two key regulators of the neuroimmune system and neural repair in the medicinal leech.Scientific reports · 2015Article
- Emerging principles governing signal transduction by pattern-recognition receptors.Cold Spring Harbor perspectives in biology · 2014Review
Corrections and comments
- Commented on by
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The cell biological principles that govern innate immune responses in Drosophila are unknown. Here, we report that Toll signaling in flies was dictated by the subcellular localization of the adaptor protein dMyD88. dMyD88 was located at the plasma membrane by a process dependent on a C-terminal phosphoinositide-binding domain. In vivo analysis revealed that lipid binding by dMyD88 was necessary for its antimicrobial and developmental functions as well as for the recruitment of the downstream cytosolic adaptor Tube to the cell surface. These data are reminiscent of the interactions between the mammalian Toll adaptors MyD88 and TIRAP with one major exception. In the mammalian system, MyD88 is the cytosolic adaptor that depends on the phosphoinositide-binding protein TIRAP for its recruitment to the cell surface. We therefore propose that dMyD88 is the functional homolog of TIRAP and that both proteins function as sorting adaptors to recruit downstream signaling adaptors to activated receptors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.