ArticleAmerican journal of obstetrics and gynecology2012
Autism risk in small- and large-for-gestational-age infants.
Article in American journal of obstetrics and gynecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
72 citing papers in PubMed, 5 syntheses or guidelines pooled it, 130 citations in OpenAlex.
- Hypertensive disorders of pregnancy and childhood neurodevelopment: A systematic review and meta-analysis.PLoS medicine · 2025Pooled it
- The early life growth of head circumference, weight, and height in infants with autism spectrum disorders: a systematic review.BMC pediatrics · 2023Pooled it
- The Association between Threatened Abortion and the Risk of Autism Spectrum Disorders among Children: A Meta-Analysis.BioMed research international · 2023Pooled it
- The association between gestational diabetes and ASD and ADHD: a systematic review and meta-analysis.Scientific reports · 2021Pooled it
- The Association Between High Birth Weight and Long-Term Outcomes-Implications for Assisted Reproductive Technologies: A Systematic Review and Meta-Analysis.Frontiers in pediatrics · 2021Pooled it
- Pre-pregnancy underweight and obesity are positively associated with small-for-gestational-age infants in a Chinese population.Scientific reports · 2019Trial
- Modified Checklist for Autism in Toddlers in a Neonatal High-Risk Population.JAMA network open · 2026Article
- Risk Factors for Autism Spectrum Disorder in Individuals Born Preterm: A Systematic Review and Meta-Analysis of Population-Based Studies.Biological psychiatry global open science · 2025Article
- Neonatal risk factors associated with autism spectrum disorders: an umbrella review.Clinical and experimental pediatrics · 2024Article
- Obstetrical and neonatal outcomes after vitrified-warmed blastocyst transfer in day 1 rescue intracytoplasmic sperm injection cycles: a retrospective cohort study.Journal of assisted reproduction and genetics · 2024Article
- A case-control study on pre-, peri-, and neonatal risk factors associated with autism spectrum disorder among Armenian children.Scientific reports · 2024Article
- Environmental Risk Factors in Autism Spectrum Disorder: A Narrative Review.Current medicinal chemistry · 2024Review
- The effect of an extended culture period on birth weight among singletons born after single or double vitrified embryo transfer.Frontiers in endocrinology · 2024Article
- [Neuropsychological development of large for gestational age infants at the age of 12 months].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023Article
- Paternal lipopolysaccharide exposure induced intrauterine growth restriction via the inactivation of placental MEST/PI3K/AKT pathway in mice.Archives of toxicology · 2023Article
- Gestational Age in Autistic Children and Adolescents: Prevalence and Effects on Autism Phenotype.Journal of autism and developmental disorders · 2023Article
- Article
- Associations of preterm and early-term birth with suspected developmental coordination disorder: a national retrospective cohort study in children aged 3-10 years.World journal of pediatrics : WJP · 2023Article
- Predictors of autism spectrum disorder diagnosis in a spanish sample of preterm children with very low birthweight: A cross-sectional study.Health science reports · 2023Article
- Association of birthweight centiles and early childhood development of singleton infants born from 37 weeks of gestation in Scotland: A population-based cohort study.PLoS medicine · 2022Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveWe sought to determine whether small-for-gestational age (SGA) and large-for-gestational age (LGA) birthweights increase autism risk. STUDY
designThis was a retrospective cohort analysis comparing children with autism (n = 20,206) within a birth cohort (n = 5,979,605). Stratification by sex and birthweight percentile (SGA, <5th or 5-10th percentile; appropriate size for gestational age [GA], >10th to <90th percentile; LGA, either 90-95th or >95th percentile) preceded Cochran-Mantel-Haenszel analysis for GA effect, and multivariate analysis.
resultsAutism risk was increased in preterm SGA (<5th percentile) infants 23-31 weeks (adjusted odds ratio [aOR], 1.60; 95% confidence interval [CI], 1.09-2.35) and 32-33 weeks (aOR, 1.83; 95% CI, 1.16-2.87), and term LGA (>95th percentile) infants 39-41 weeks (aOR, 1.16; 95% CI, 1.08-1.26), but was decreased in preterm LGA infants 23-31 weeks (aOR, 0.45; 95% CI, 0.21-0.95).
conclusionSGA was associated with autism in preterm infants, while LGA demonstrated dichotomous risk by GA, with increased risk at term, and decreased risk in the premature infants. These findings likely reflect disparate pathophysiologies, and should influence prenatal counseling, pediatric autism screening, and further autism research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.