Evidence map›Paper›PMID 22464010›Full record

ReviewPublic health nutrition2013

Aetiological factors behind adipose tissue inflammation: an unexplored research area.

Bernt J von Scholten, Erik N Andresen, Thorkild I A Sørensen, Tine Jess

Open access · bronzeAbstract readReview
In one paragraph

Review in Public health nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. ADV36 adipogenic adenovirus in human liver disease.World journal of gastroenterology · 2014
    Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bernt J von ScholtenInstitute of Preventive Medicine, Copenhagen University Hospital, Copenhagen, Denmark.
Erik N Andresen
Thorkild I A Sørensen
Tine Jess
Copenhagen University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDespite extensive research into the biological mechanisms behind obesity-related inflammation, knowledge of environmental and genetic factors triggering such mechanisms is limited. In the present narrative review we present potential determinants of adipose tissue inflammation and suggest ways ahead for future research in the field.

designWe searched the literature for potential determinants of obesity with inflammation through MEDLINE by applying the MeSH headings 'obesity' and 'inflammation' in combination with specific terms for a series of environmental and genetic factors.

resultsNumerous articles reported on the association between environmental or genetic factors and respectively obesity and inflammation, whereas only a few studies assessed obesity and inflammation as a combined outcome. Among suggested determinants for obesity with inflammation were Adenovirus-36, the gut microbiota, trans-fatty acids, and the four genes FTO, MC4R, TNF-α and LEPR.

conclusionsWe present a limited number of factors potentially contributing to the development of obesity with inflammation, while concluding that overall the area is indeed sparsely investigated. We present ideas for future studies that can identify relevant aetiological factors. This identification is essential for targeted prevention of obesity with inflammation and the clinical consequences thereof.

Indexed as

AdenoviridaeAdipose TissueEnvironmentAlpha-Ketoglutarate-Dependent Dioxygenase FTODietary FatsGastrointestinal TractHumansInflammationMetagenomeObesityProteinsReceptor, Melanocortin, Type 4Receptors, LeptinTrans Fatty AcidsTumor Necrosis Factor-alphaAlpha-Ketoglutarate-Dependent Dioxygenase FTODietary FatsFTO protein, humanMC4R protein, humanProteinsReceptor, Melanocortin, Type 4Receptors, LeptinTrans Fatty AcidsTumor Necrosis Factor-alpha

Identifiers

PMID22464010
PMCPMC10271772
OpenAlexW2068706952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.