ArticleDiagnostic pathology2012
Validation of diagnostic accuracy using digital slides in routine histopathology.
Article in Diagnostic pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- The performance of digital microscopy for primary diagnosis in human pathology: a systematic review.Virchows Archiv : an international journal of pathology · 2019Pooled it
- Validating whole slide imaging for diagnostic purposes in pathology: guideline from the College of American Pathologists Pathology and Laboratory Quality Center.Archives of pathology & laboratory medicine · 2013Guideline
- Whole Slide Imaging Versus Microscopy for Primary Diagnosis in Surgical Pathology: A Multicenter Blinded Randomized Noninferiority Study of 1992 Cases (Pivotal Study).The American journal of surgical pathology · 2018Trial
- A guide for the deployment, validation, and accreditation of clinical digital pathology tools.Journal of pathology informatics · 2026Article
- Digital pathology systems enabling quality patient care.Genes, chromosomes & cancer · 2023Review
- Digital pathology: the effect of experience on visual search behavior.Journal of medical imaging (Bellingham, Wash.) · 2022Article
- Integrating digital pathology into clinical practice.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Review
- Validation of digital microscopy: Review of validation methods and sources of bias.Veterinary pathology · 2022Review
- Digital validation of breast biomarkers (ER, PR, AR, and HER2) in cytology specimens using three different scanners.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- Poor Endometrial Proliferation After Clomiphene is Associated With Altered Estrogen Action.The Journal of clinical endocrinology and metabolism · 2021Article
- Remote Reporting from Home for Primary Diagnosis in Surgical Pathology: A Tertiary Oncology Center Experience during the COVID-19 Pandemic.Journal of pathology informatics · 2021Article
- Validation of a digital pathology system including remote review during the COVID-19 pandemic.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- Precise Identification of Cell and Tissue Features Important for Histopathologic Diagnosis by a Whole Slide Imaging System.Journal of pathology informatics · 2020Article
- Whole slide imaging equivalency and efficiency study: experience at a large academic center.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019Article
- Validation of digital microscopy in the histopathological diagnoses of oral diseases.Virchows Archiv : an international journal of pathology · 2018Article
- The Empirical Foundations of Telepathology: Evidence of Feasibility and Intermediate Effects.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2017Review
- A novel quantitative immunohistochemistry method for precise protein measurements directly in formalin-fixed, paraffin-embedded specimens: analytical performance measuring HER2.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2017Article
- Rationale for Quality Assurance in Fecal Egg Monitoring of Soil-Transmitted Helminthiasis.The American journal of tropical medicine and hygiene · 2016Article
- A novel approach for quantitative assessment of mucosal damage in inflammatory bowel disease.Diagnostic pathology · 2013Article
- What is a virtual multidisciplinary team (vMDT)?British journal of cancer · 2013Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRobust hardware and software tools have been developed in digital microscopy during the past years for pathologists. Reports have been advocated the reliability of digital slides in routine diagnostics. We have designed a retrospective, comparative study to evaluate the scanning properties and digital slide based diagnostic accuracy.
methods8 pathologists reevaluated 306 randomly selected cases from our archives. The slides were scanned with a 20× Plan-Apochromat objective, using a 3-chip Hitachi camera, resulting 0.465 μm/pixel resolution. Slide management was supported with dedicated Data Base and Viewer software tools. Pathologists used their office PCs for evaluation and reached the digital slides via intranet connection. The diagnostic coherency and uncertainty related to digital slides and scanning quality were analyzed.
resultsGood to excellent image quality of slides was recorded in 96%. In half of the critical 61 digital slides, poor image quality was related to section folds or floatings. In 88.2% of the studied cases the digital diagnoses were in full agreement with the consensus. Out of the overall 36 incoherent cases, 7 (2.3%) were graded relevant without any recorded uncertainty by the pathologist. Excluding the non-field specific cases from each pathologist's record this ratio was 1.76% of all cases.
conclusionsOur results revealed that: 1) digital slide based histopathological diagnoses can be highly coherent with those using optical microscopy; 2) the competency of pathologists is a factor more important than the quality of digital slide; 3) poor digital slide quality do not endanger patient safety as these errors are recognizable by the pathologist and further actions for correction could be taken. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1913324336747310.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.