ArticleMolecular microbiology2012
Role of a Candida albicans Nrm1/Whi5 homologue in cell cycle gene expression and DNA replication stress response.
Article in Molecular microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Article
- Genomic factors shape carbon and nitrogen metabolic niche breadth across Saccharomycotina yeasts.Science (New York, N.Y.) · 2024Article
- Genomic and ecological factors shaping specialism and generalism across an entire subphylum.bioRxiv : the preprint server for biology · 2023Article
- Article
- Essential Roles of Ribonucleotide Reductases under DNA Damage and Replication Stresses in Cryptococcus neoformans.Microbiology spectrum · 2022Article
- Characterization of a novel separase-interacting protein and candidate new securin, Eip1p, in the fungal pathogenMolecular biology of the cell · 2019Article
- The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans.PLoS genetics · 2019Article
- Regulation ofJournal of fungi (Basel, Switzerland) · 2019Review
- Integration of Growth and Cell Size via the TOR Pathway and the Dot6 Transcription Factor inGenetics · 2019Article
- Protein-Protein Interactions inFrontiers in microbiology · 2019Review
- The evolution of a G1/S transcriptional network in yeasts.Current genetics · 2018Review
- A Global Analysis of Kinase Function inFrontiers in cellular and infection microbiology · 2018Article
- Disruption of the transcription factors Thi2p and Nrm1p alleviates the post-glucose effect on xylose utilization inBiotechnology for biofuels · 2018Article
- Gene duplication and co-evolution of G1/S transcription factor specificity in fungi are essential for optimizing cell fitness.PLoS genetics · 2017Article
- Cell cycle regulated transcription: from yeast to cancer.F1000Research · 2016Review
- Review
- Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6.Molecular and cellular biology · 2013Article
- Deciphering the transcriptional-regulatory network of flocculation in Schizosaccharomyces pombe.PLoS genetics · 2012Article
- Regulation of themSphereArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
To explore cell cycle regulation in the dimorphic fungus Candida albicans, we identified and characterized CaNrm1, a C. albicans homologue of the Saccharomyces cerevisiae Whi5 and Nrm1 transcription inhibitors that, analogous to mammalian Rb, regulate the cell cycle transcription programme during the G1 phase. CaNRM1 is able to complement the phenotypes of both whi5 and nrm1 mutants in S. cerevisiae. In C. albicans, global transcription analysis of the CaNRM1 deletion mutant reveals a preferential induction of G1- and G1/S-specific genes. CaNrm1 interacts genetically with the C. albicans MBF functional homologue, and physically with its subunit CaSwi4. Similar to S. cerevisiae Whi5, CaNrm1 subcellular localization oscillates with the cell cycle between the nucleus and the cytoplasm. Deletion of CaNRM1 further results in increased resistance to hydroxyurea, an inhibitor of DNA replication; analysis of the expression of ribonucleotide reductase, the target of hydroxyurea, suggests that its transcriptional induction in response to hydroxyurea is regulated via CaNrm1, and biochemical analysis shows that hydroxyurea causes disruption of the interaction of CaNrm1 with CaSwi4. Furthermore, induction of the hyphal-specific genes is dampened under certain conditions in the Canrm1(-/-) mutant, suggesting that the cell cycle transcription programme can influence the morphogenetic transcription programme of C. albicans.
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