Evidence map›Paper›PMID 22462786›Full record

ReviewExpert review of proteomics2012

Microscale 2D separation systems for proteomic analysis.

Xin Xu, Ke Liu, Z Hugh Fan

Abstract readReview
In one paragraph

Review in Expert review of proteomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xin XuInterdisciplinary Microsystems Group, Department of Mechanical & Aerospace Engineering, University of Florida, Gainesville, FL 32611-6250, USA.
Ke Liu
Z Hugh Fan

Funding

Mentored Quantitative Research Career Development AwardK25CA149080 · NCI · UNIVERSITY OF FLORIDA · PI FAN, Z. HUGH · 2011 to 2015
$897k
Two-Dimensional Electrophoresis Device for Biomarker DetectionR21RR024397 · NCRR · UNIVERSITY OF FLORIDA · PI FAN, Z. HUGH · 2009 to 2010
$535k
Microfluidics-enabled Immunoassay Array for Multianalyte DetectionR21GM103535 · NIGMS · UNIVERSITY OF FLORIDA · PI FAN, Z. HUGH · 2012 to 2013
$342k
Microfluidics-enabled Immunoassay Array for Multianalyte DetectionR21RR026215 · NCRR · UNIVERSITY OF FLORIDA · PI FAN, Z. HUGH · 2011 to 2011
$173k
NCI NIH HHS K25 CA149080NCI NIH HHS K25CA149080NCRR NIH HHS R21 RR024397NCRR NIH HHS R21RR024397NCRR NIH HHS R21 RR026215NCRR NIH HHS R21RR026215NIGMS NIH HHS R21 GM103535
6 · The paper itself

Abstract

Microscale 2D separation systems have been implemented in capillaries and microfabricated channels. They offer advantages of faster analysis, higher separation efficiency and less sample consumption than the conventional methods, such as liquid chromatography (LC) in a column and slab gel electrophoresis. In this article, we review their recent advancement, focusing on three types of platforms, including 2D capillary electrophoresis (CE), CE coupling with capillary LC, and microfluidic devices. A variety of CE and LC modes have been employed to construct 2D separation systems via sophistically designed interfaces. Coupling of different separation modes has also been realized in a number of microfluidic devices. These separation systems have been applied for the proteomic analysis of various biological samples, ranging from a single cell to tumor tissues.

Indexed as

Electrophoresis, CapillaryChromatography, LiquidChromatography, Reverse-PhaseHumansMicrofluidic Analytical TechniquesProteomeProteomicsProteome

Identifiers

PMID22462786
PMCPMC3371270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.