ArticleBMC infectious diseases2012
Cognitive deficits following exposure to pneumococcal meningitis: an event-related potential study.
Article in BMC infectious diseases, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- Stroke in children and adolescents: Analysis of electrophysiological and behavioral assessment findings of auditory processing.Clinics (Sao Paulo, Brazil) · 2023Trial
- Neurodevelopmental Impairments in Adult Psychosomatic Patients.Journal of clinical medicine · 2024Article
- A review of the auditory-gut-brain axis.Frontiers in neuroscience · 2023Review
- Uncovering the neuroprotective effect of vitamin B12 in pneumococcal meningitis: insights into its pleiotropic mode of action at the transcriptional level.Frontiers in immunology · 2023Article
- ERP markers are associated with neurodevelopmental outcomes in 1-5 month old infants in rural Africa and the UK.NeuroImage · 2020Article
- The burden of pneumococcal meningitis in Austrian children between 2001 and 2008.European journal of pediatrics · 2014Article
- Biomedical risk, psychosocial influences, and developmental outcomes: lessons from the pediatric HIV population in Africa.New directions for child and adolescent development · 2014Review
- Long-term sequelae of childhood bacterial meningitis.Current infectious disease reports · 2013Article
- Slums are not places for children to live: vulnerabilities, health outcomes, and possible interventions.Advances in pediatrics · 2013Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundPneumococcal meningitis (PM) is a severe and life-threatening disease that is associated with cognitive impairment including learning difficulties, cognitive slowness, short-term memory deficits and poor academic performance. There are limited data on cognitive outcomes following exposure to PM from Africa mainly due to lack of culturally appropriate tools. We report cognitive processes of exposed children as measured by auditory and visual event-related potentials.
methodsSixty-five children (32 male, mean 8.4 years, SD 3.0 years) aged between 4-15 years with a history of PM and an age-matched control group of 93 children (46 male; mean 8.4 years, SD 2.7 years) were recruited from a well-demarcated study area in Kilifi. In the present study, both baseline to peak and peak-to-peak amplitude differences are reported.
resultsChildren with a history of pneumococcal meningitis had significantly longer auditory P1 and P3a latencies and smaller P1 amplitudes compared to unexposed children. In the visual paradigm, children with PM seemingly lacked a novelty P3a component around 350 ms where control children had a maximum, and showed a lack of stimulus differentiation at Nc. Further, children with exposure to PM had smaller peak to peak amplitude (N2-P1) compared to unexposed children.
conclusionThe results suggest that children with a history of PM process novelty differently than do unexposed children, with slower latencies and reduced or absent components. This pattern suggests poorer auditory attention and/or cognitive slowness and poorer visual attention orienting, possibly due to disruption in the functions of the lateral prefrontal and superior temporal cortices. ERPs may be useful for assessment of the development of perceptual-cognitive functions in post brain-injury in African children by providing an alternate way of assessing cognitive development in patient groups for whom more typical standardized neuropsychological assessments are unavailable.
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Registered trials
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