ArticleBritish journal of pharmacology2012
5-HT(1B) receptors inhibit glutamate release from primary afferent terminals in rat medullary dorsal horn neurons.
Article in British journal of pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Targeting GCell reports. Medicine · 2026Article
- The Role of Serotonergic System in Parkinson's Disease-Related Pain.Neuroscience bulletin · 2026Review
- Serotonin and psilocybin activate 5-HTNature communications · 2025Article
- Temporomandibular disorders and mental health: shared etiologies and treatment approaches.The journal of headache and pain · 2025Review
- Review
- Understanding the Biological Relationship between Migraine and Depression.Biomolecules · 2024Review
- The Serotonergic System and Amyotrophic Lateral Sclerosis: A Review of Current Evidence.Cellular and molecular neurobiology · 2023Review
- Differential Serotonergic Modulation of Synaptic Inputs to the Olfactory Cortex.International journal of molecular sciences · 2023Article
- Potential mechanisms of acupuncture for neuropathic pain based on somatosensory system.Frontiers in neuroscience · 2022Review
- Effect of dural inflammatory soup application on activation and sensitization markers in the caudal trigeminal nucleus of the rat and the modulatory effects of sumatriptan and kynurenic acid.The journal of headache and pain · 2021Article
- Inflammation induces developmentally regulated sumatriptan inhibition of spinal synaptic transmission.British journal of pharmacology · 2020Article
- Ketamine induces immediate and delayed alterations of OCD-like behavior.Psychopharmacology · 2020Article
- Serotonin gating of cortical and thalamic glutamate inputs onto principal neurons of the basolateral amygdala.Neuropharmacology · 2017Article
- Electrophysiological characterization of activation state-dependent Ca(v)2 channel antagonist TROX-1 in spinal nerve injured rats.Neuroscience · 2015Article
- Serotonin, 5HT1 agonists, and migraine: new data, but old questions still not answered.Current opinion in supportive and palliative care · 2014Review
- Mechanisms of acupuncture-electroacupuncture on persistent pain.Anesthesiology · 2014Review
- Optogenetic recruitment of dorsal raphe serotonergic neurons acutely decreases mechanosensory responsivity in behaving mice.PloS one · 2014Article
- Reduced GABAA receptor α6 expression in the trigeminal ganglion enhanced myofascial nociceptive response.Neuroscience · 2013Article
- What would 5-HT do? Regional diversity of 5-HT(1) receptor modulation of primary afferent neurotransmission.British journal of pharmacology · 2012Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAlthough 5-HT(1B) receptors are expressed in trigeminal sensory neurons, it is still not known whether these receptors can modulate nociceptive transmission from primary afferents onto medullary dorsal horn neurons. EXPERIMENTAL APPROACH: Primary afferent-evoked EPSCs were recorded from medullary dorsal horn neurons of rat horizontal brain stem slices using a conventional whole-cell patch clamp technique under a voltage-clamp condition. KEY
resultsCP93129, a selective 5-HT(1B) receptor agonist, reversibly and concentration-dependently decreased the amplitude of glutamatergic EPSCs and increased the paired-pulse ratio. In addition, CP93129 reduced the frequency of spontaneous miniature EPSCs without affecting the current amplitude. The CP93129-induced inhibition of EPSCs was significantly occluded by GR55562, a 5-HT(1B/1D) receptor antagonist, but not LY310762, a 5-HT(1D) receptor antagonist. Sumatriptan, an anti-migraine drug, also decreased EPSC amplitude, and this effect was partially blocked by either GR55562 or LY310762. On the other hand, primary afferent-evoked EPSCs were mediated by the Ca(2+) influx passing through both presynaptic N-type and P/Q-type Ca(2+) channels. The CP93129-induced inhibition of EPSCs was significantly occluded by ω-conotoxin GVIA, an N-type Ca(2+) channel blocker. CONCLUSIONS AND IMPLICATIONS: The present results suggest that the activation of presynaptic 5-HT(1B) receptors reduces glutamate release from primary afferent terminals onto medullary dorsal horn neurons, and that 5-HT(1B) receptors could be, at the very least, a potential target for the treatment of pain from orofacial tissues.
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