Evidence map›Paper›PMID 22461954›Full record

ArticleInternational journal of physiology, pathophysiology and pharmacology2012

The link between angiotensin II-mediated anxiety and mood disorders with NADPH oxidase-induced oxidative stress.

Feng Liu, Jennifer Havens, Qi Yu, Gang Wang, Robin L Davisson, Virginia M Pickel, Costantino Iadecola

Abstract read
In one paragraph

Article in International journal of physiology, pathophysiology and pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Systematically exploring repurposing effects of antihypertensives.Pharmacoepidemiology and drug safety · 2022
    Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Significance of psychosocial factors in cardiology: update 2018 : Position paper of the German Cardiac Society.Clinical research in cardiology : official journal of the German Cardiac Society · 2019
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Feng Liu
Jennifer Havens
Qi Yu
Gang Wang
Robin L Davisson
Virginia M Pickel
Costantino Iadecola

Funding

Radiotelemetry CoreP01HL096571 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI DAVISSON, ROBIN L · 2009 to 2013
$8.8M
ULTRASTRUCTURE OF MESOLIMBIC TRANSMITTER INTERACTIONSR37MH040342 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI PICKEL, VIRGINIA M · 1988 to 2007
$2.5M
ULTRASTRUCTURE OF MESOLIMBIC TRANSMITTER INTERACTIONSR01MH040342 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI PICKEL, VIRGINIA M · 1985 to 2012
$1.7M
NHLBI NIH HHS P01 HL096571NIMH NIH HHS R01 MH040342NIMH NIH HHS R37 MH040342
6 · The paper itself

Abstract

The renin-angiotensin system (RAS) and its active peptide angiotensin II (AngII) have major involvements not only in hypertension but also in mood and anxiety disorders. Substantial evidence supports the notion that AngII acts as a neuromodulator in the brain. In this review, we provide an overview of the link between the RAS and anxiety or mood disorders, and focus on recent advances in the understanding of AngII-linked, NADPH oxidase-derived oxidative stress in the central nervous system, which may underlie pathogenesis of mood and anxiety disorders.

Indexed as

angiotensin IIanxiety disorderbipolar disordermajor depressive disorderNADPH oxidasereactive oxygen speciesRenin-angiotensin system

Identifiers

PMID22461954
PMCPMC3312460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.