ArticlePloS one2012
Can the tumor deposits be counted as metastatic lymph nodes in the UICC TNM staging system for colorectal cancer?
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic value of tumor deposits for long-term oncologic outcomes in patients with stage III colorectal cancer: a systematic review and meta-analysis.International journal of colorectal disease · 2022Pooled it
- Combining tumor deposits with the number of lymph node metastases to improve the prognostic accuracy in stage III colon cancer: a post hoc analysis of the CALGB/SWOG 80702 phase III study (Alliance)Annals of oncology : official journal of the European Society for Medical Oncology · 2021Trial
- Association between the histopathologic measurement of tumor-visceral peritoneal distance and prognosis in T3 colon adenocarcinoma.Pathology oncology research : POR · 2026Article
- Tumor deposits should not be placed in the M category of TNM: A comparative survival analysis using SEER data.International journal of cancer · 2025Article
- The potential role of tumor deposits in the prognosis and TNM staging for colorectal cancer.Journal of gastrointestinal oncology · 2024Article
- Prognostic Value of Tumor Deposits in Patients with Colorectal Cancer.Journal of Cancer · 2024Article
- Negative prognostic impact of tumor deposits in stage III colorectal cancer patients.PloS one · 2024Article
- The five-item modified frailty index predicts long-term outcomes in elderly patients undergoing colorectal cancer surgery.World journal of surgical oncology · 2023Article
- Tumor deposits in colorectal cancer: Refining their definition in the TNM system.Annals of gastroenterological surgery · 2023Review
- Readjustment of nodal staging by integrating tumor deposits and positive lymph nodes in patients with stage III colon cancer: a population-based analysis.American journal of cancer research · 2023Article
- Identifying the long-term survival beneficiary of chemotherapy for stage N1c sigmoid colon cancer.Scientific reports · 2022Article
- The value of tumor deposits in evaluating colorectal cancer survival and metastasis: a population-based retrospective cohort study.World journal of surgical oncology · 2022Article
- Colorectal cancer surgery in elderly patients 80 years and older: a comparison with younger age groups.Journal of gastrointestinal oncology · 2022Article
- A Six-microRNA Signature Nomogram for Preoperative Prediction of Tumor Deposits in Colorectal Cancer.International journal of general medicine · 2022Article
- Spatiotemporal quantification of metastatic tumour cell growth and distribution in lymph nodes by whole-mount tissue 3D imaging.International journal of biological sciences · 2022Article
- Comparison of model fit and discriminatory ability of the 8th edition of the tumor-node-metastasis classification and the 9th edition of the Japanese classification to identify stage III colorectal cancer.International journal of clinical oncology · 2021Article
- Prognostic value of tumor deposits in locally advanced rectal cancer: a retrospective study with propensity score matching.International journal of clinical oncology · 2021Article
- Development and validation of a novel prognostic nomogram including tumor deposits could better predict survival for colorectal cancer: a population-based study.Annals of translational medicine · 2021Article
- Preoperative prediction of tumour deposits in rectal cancer by an artificial neural network-based US radiomics model.European radiology · 2020Article
- Reconsidering the prognostic significance of tumour deposit count in the TNM staging system for colorectal cancer.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe 7th edition of AJCC staging manual implicitly states that only T1 and T2 lesions that lack regional lymph node metastasis but have tumor deposit(s) will be classified in addition as N1c, though it is not consistent in that pN1c is also an option for pT3/T4a tumors in the staging table. Nevertheless, in this TNM classification, how to classify tumor deposits (TDs) in colorectal cancer patients with lymph node metastasis (LNM) and TDs simultaneously is still not clear. The aim of this study is to investigate the possibility of counting TDs as metastatic lymph nodes in TNM classification and to identify its prognostic value for colorectal cancer patients. METHODS AND
resultsIn this retrospective study, 513 cases of colorectal cancer with LNM were reviewed. We proposed a novel pN (npN) category in which TDs were counted as metastatic lymph nodes in the TNM classification. Cancer-specific survival according to the npN or pN category was analyzed using Kaplan-Meier survival curves. Univariate and multivariate analyses were performed to identify significant prognostic factors. Harrell's C statistic was used to test the predictive capacity of the prognostic models. The results revealed that the TD was a significant prognostic factor in colorectal cancer. Univariate and multivariate analyses uniformly indicated that the npN category was significantly correlated with prognosis. The results of Harrell's C statistical analysis demonstrated that the npN category exhibited a superior predictive capacity compared to the pN category of the 7th edition TNM classification. Moreover, we also found no significant prognostic differences in patients with or without TD in the same npN categories.
conclusionsThe counting of TDs as metastatic lymph nodes in the TNM classification system is potentially superior to the classification in the 7th edition of the TNM staging system to assess prognosis and survival for colorectal cancer patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.