ArticlePloS one2012
The rph2 gene is responsible for high level resistance to phosphine in independent field strains of Rhyzopertha dominica.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Genome-Wide Identification and Characterization of Heat Shock Proteins in the Stored-Product PestInsects · 2025Article
- Transcriptome profiling and in silico docking analysis of phosphine resistance in rice weevil, Sitophilus oryzae (Coleoptera: Curculionidae).Journal of insect science (Online) · 2023Article
- Current status of phosphine resistance in Indian field populations of Tribolium castaneum and its influence on antioxidant enzyme activities.Scientific reports · 2023Article
- Comparison of phenotypic and genotypic frequency of phosphine resistance in select field populations of Tribolium castaneum from India.Molecular biology reports · 2023Article
- Differential Activities of Antioxidant Enzymes, Superoxide Dismutase, Peroxidase, and Catalase vis-à-vis Phosphine Resistance in Field Populations of Lesser Grain Borer (Antioxidants (Basel, Switzerland) · 2023Article
- Fitness costs of resistance to insecticides in insects.Frontiers in physiology · 2023Review
- Preliminary Study on the Differences in Hydrocarbons Between Phosphine-Susceptible and -Resistant Strains ofMolecules (Basel, Switzerland) · 2020Article
- Variant Linkage Analysis UsingGenetics · 2018Article
- Genetic Conservation of Phosphine Resistance in the Rice Weevil Sitophilus oryzae (L.).The Journal of heredity · 2016Article
- Phosphine resistance in India is characterised by a dihydrolipoamide dehydrogenase variant that is otherwise unobserved in eukaryotes.Heredity · 2015Article
- Inheritance and characterization of strong resistance to phosphine in Sitophilus oryzae (L.).PloS one · 2015Article
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5 authors.
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Abstract
The lesser grain borer Rhyzopertha dominica (F.) is one of the most destructive insect pests of stored grain. This pest has been controlled successfully by fumigation with phosphine for the last several decades, though strong resistance to phosphine in many countries has raised concern about the long term usefulness of this control method. Previous genetic analysis of strongly resistant (SR) R. dominica from three widely geographically dispersed regions of Australia, Queensland (SR(QLD)), New South Wales (SR(NSW)) and South Australia (SR(SA)), revealed a resistance allele in the rph1 gene in all three strains. The present study confirms that the rph1 gene contributes to resistance in a fourth strongly resistant strain, SR2(QLD), also from Queensland. The previously described rph2 gene, which interacts synergistically with rph1 gene, confers strong resistance on SR(QLD) and SR(NSW). We now provide strong circumstantial evidence that weak alleles of rph2, together with rph1, contribute to the strong resistance phenotypes of SR(SA) and SR2(QLD). To test the notion that rph1 and rph2 are solely responsible for the strong resistance phenotype of all resistant R. dominica, we created a strain derived by hybridising the four strongly resistant lines. Following repeated selection for survival at extreme rates of phosphine exposure, we found only slightly enhanced resistance. This suggests that a single sequence of genetic changes was responsible for the development of resistance in these insects.
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