ArticleClinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases2011
Osteoporosis in patients with subclinical hypothyroidism treated with thyroid hormone.
Article in Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Hypothyroidism and Mandibular Cortical Alterations Evaluated on Panoramic Radiography: A Cross-Sectional Study in Women.Healthcare (Basel, Switzerland) · 2025Article
- Awareness, Knowledge, and Health Beliefs Regarding Osteoporosis among Hypothyroid Patients in Turkey: An Observational Study.Journal of bone metabolism · 2025Article
- Mechanosignaling in Osteoporosis: When Cells Feel the Force.International journal of molecular sciences · 2025Review
- Musculoskeletal Manifestations in Sjogren's Syndrome: An Orthopedic Point of View.Journal of clinical medicine · 2021Review
- The Influence of Thyroid Pathology on Osteoporosis and Fracture Risk: A Review.Diagnostics (Basel, Switzerland) · 2020Review
- High-Throughput Metabolomics Discovers Metabolic Biomarkers and Pathways to Evaluating the Efficacy and Exploring Potential Mechanisms of Osthole Against Osteoporosis Based on UPLC/Q-TOF-MS Coupled With Multivariate Data Analysis.Frontiers in pharmacology · 2020Article
- Controlled Delivery of Salmon Calcitonin Using Thermosensitive Triblock Copolymer Depot for Treatment of Osteoporosis.ACS omega · 2019Article
- Dementia and osteoporosis in a geriatric population: Is there a common link?World journal of orthopedics · 2017Article
- A Study to Assess the Validity of Estimation of Serum Ostase Level in Hyperthyroid and Hypothyroid Cases.Journal of clinical and diagnostic research : JCDR · 2016Article
- Treatment of subclinical hypothyroidism does not affect bone mass as determined by dual-energy X-ray absorptiometry, peripheral quantitative computed tomography and quantitative bone ultrasound in Spanish women.Archives of medical science : AMS · 2015Article
- Breast cancer survivorship: a comprehensive review of long-term medical issues and lifestyle recommendations.The Permanente journal · 2015Review
- Effects of Levothyroxine and thyroid stimulating hormone on bone loss in patients with primary hypothyroidism.Journal of research in pharmacy practice · 2014Article
- A case of bilateral stress fractures in an old woman: three years of pain.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases · 2014Article
- Risk factors and prevalence of osteoporosis in premenopausal women from poor economic backgrounds in Colombia.International journal of women's health · 2013Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveto estimate the prevalence of osteoporosis in patients being treated with thyroid hormone.
methodcross-sectional retrospective study of primary care patients. EXPERIMENTAL GROUP: patients diagnosed with subclinical hypothyroidism receiving thyroid hormone replacement therapy. CONTROL GROUP: patients not receiving replacement therapy. Once the sample was selected its members were summoned to complete a clinical questionnaire and undergo a bone density scan with a validated measuring device. The description of qualitative data was done in absolute frequencies and percentages and that of the quantitative data as mean standard deviation, median. In the comparison of qualitative data between groups we used the Chi-square test and contingency tables by rearranging the percentages of several variables.
results182 patients were studied (112 experimental and 70 control), diagnosed with subclinical hypothyroidism. The average age at diagnosis was 42.5 and 41.2 years, respectively. 32.7% and 33.2% were smokers. In the experimental group the coexistence of two or more cardiovascular risk factors was detected in 5.7% of the patients. Mean TSH was 6.67 mU/L, mean free T(4) 1,04 ng/dl. 67% of the patients studied had some level of bone loss: 87% osteopenia and 14% osteoporosis. 56% of those suffering from bone less were women. With regard to the size of the thyroid hormone treatment, only 12% received 150 μg/day or more. 61% had received treatment for between 5 and 10 years and 19.5% for more than 10 years.
conclusionsthere is a high prevalence of bone loss in patients with subclinical hypothyroidism treated with exogenous thyroxin.
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Identifiers
22461829PMC3279063W1591103865What OpenQuestion holds
Registered trials
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