ArticleFrontiers in microbiology2012
Increased levels of multiresistant bacteria and resistance genes after wastewater treatment and their dissemination into lake geneva, Switzerland.
Article in Frontiers in microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 1 of them a synthesis that pooled it.
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Who cites it
110 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hospital Wastewater as a Reservoir for Antibiotic Resistance Genes: A Meta-Analysis.Frontiers in public health · 2020Pooled it
- Genomic Insight into the Mobility of Antibiotic Resistance Genes in Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2026Article
- Evaluating Antibiotic Resistance in Urban Rivers and Coral Reefs of Belize: Evidence for Hotspots and a Potential Screening Tool.GeoHealth · 2026Article
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- Wastewater microbiology: occurrence and prevalence of antibiotic-resistant extended-spectrumJournal of water and health · 2025Article
- Riverine antibiotic resistome along an anthropogenic gradient.Frontiers in microbiology · 2025Article
- Unde venis? Bacterial resistance from environmental reservoirs to lettuce: tracking microbiome and resistome over a growth period.FEMS microbiology ecology · 2024Article
- Isolation and Characterization of Extended-Spectrum β-Lactamase ProducingIndian journal of microbiology · 2024Article
- The Role of Wastewater Treatment Plants in Dissemination of Antibiotic Resistance: Source, Measurement, Removal and Risk Assessment.Antibiotics (Basel, Switzerland) · 2024Review
- Antibiotic resistance in livestock, environment and humans: One Health perspective.Journal of animal science and technology · 2024Review
- Comparison of the Antibiotic Resistance ofPathogens (Basel, Switzerland) · 2024Article
- Scenario-based assessment of fecal pathogen sources affecting bathing water quality: novel treatment options to reduce norovirus andFrontiers in microbiology · 2024Article
- Chronic industrial perturbation and seasonal change induces shift in the bacterial community from gammaproteobacteria to betaproteobacteria having catabolic potential for aromatic compounds at Amlakhadi canal.World journal of microbiology & biotechnology · 2023Article
- Differential effects of wastewater treatment plant effluents on the antibiotic resistomes of diverse river habitats.The ISME journal · 2023Article
- Metagenomic analysis reveals the dissemination mechanisms and risks of resistance genes in plateau lakes.iScience · 2023Article
- Reduced Antibiotic Resistance in the Rhizosphere ofBiology · 2023Article
- Effects of UV-B radiation on epiphytic bacterial communities on male and female Sargassum thunbergii.Scientific reports · 2023Article
- Comparing the Efficacy of MALDI-TOF MS and Sequencing-Based Identification Techniques (Sanger and NGS) to Monitor the Microbial Community of Irrigation Water.Microorganisms · 2023Article
50 more citing papers are in PubMed but not listed here.
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At present, very little is known about the fate and persistence of multiresistant bacteria (MRB) and their resistance genes in natural aquatic environments. Treated, but partly also untreated sewage of the city of Lausanne, Switzerland is discharged into Vidy Bay (Lake Geneva) resulting in high levels of contamination in this part of the lake. In the present work we have studied the prevalence of MRB and resistance genes in the wastewater stream of Lausanne. Samples from hospital and municipal raw sewage, treated effluent from Lausanne's wastewater treatment plant (WTP) as well as lake water and sediment samples obtained close to the WTP outlet pipe and a remote site close to a drinking water pump were evaluated for the prevalence of MRB. Selected isolates were identified (16S rRNA gene fragment sequencing) and characterized with regards to further resistances, resistance genes, and plasmids. Mostly, studies investigating this issue have relied on cultivation-based approaches. However, the limitations of these tools are well known, in particular for environmental microbial communities, and cultivation-independent molecular tools should be applied in parallel in order to take non-culturable organisms into account. Here we directly quantified the sulfonamide resistance genes sul1 and sul2 from environmental DNA extracts using TaqMan real-time quantitative PCR. Hospital sewage contained the highest load of MRB and antibiotic resistance genes (ARGs). Wastewater treatment reduced the total bacterial load up to 78% but evidence for selection of extremely multiresistant strains and accumulation of resistance genes was observed. Our data clearly indicated pollution of sediments with ARGs in the vicinity of the WTP outlet. The potential of lakes as reservoirs of MRB and potential risks are discussed.
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