ArticleFrontiers in systems neuroscience2012
Olfactory aversive conditioning alters olfactory bulb mitral/tufted cell glomerular odor responses.
Article in Frontiers in systems neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Generalization of fear learning is shaped by inhibitory sensory processing in mice.Nature communications · 2026Article
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- Olfactory neurogenesis and its role in fear memory modulation.Frontiers in behavioral neuroscience · 2023Review
- The impact of familiarity on cortical taste coding.Current biology : CB · 2022Article
- The human olfactory bulb processes odor valence representation and cues motor avoidance behavior.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- NIH Workshop Report: sensory nutrition and disease.The American journal of clinical nutrition · 2021Article
- Odor hedonics coding in the vertebrate olfactory bulb.Cell and tissue research · 2021Review
- Smell-Based Memory Training: Evidence of Olfactory Learning and Transfer to the Visual Domain.Chemical senses · 2020Article
- Predation threats for a 24-h period activated the extension of axons in the brains of Xenopus tadpoles.Scientific reports · 2020Article
- Aversive Learning Increases Release Probability of Olfactory Sensory Neurons.Current biology : CB · 2020Article
- Aversive learning-induced plasticity throughout the adult mammalian olfactory system: insights across development.Journal of bioenergetics and biomembranes · 2019Review
- The Value of Homework: Exposure to Odors in the Home Cage Enhances Odor-Discrimination Learning in Mice.Chemical senses · 2019Article
- Olfactory Bulb Muscarinic Acetylcholine Type 1 Receptors Are Required for Acquisition of Olfactory Fear Learning.Frontiers in behavioral neuroscience · 2019Article
- Pavlovian Olfactory Fear Conditioning: Its Neural Circuity and Importance for Understanding Clinical Fear-Based Disorders.Frontiers in molecular neuroscience · 2019Review
- Pheromone-Induced Odor Associative Fear Learning in Rats.Scientific reports · 2018Article
- Learning-Dependent and -Independent Enhancement of Mitral/Tufted Cell Glomerular Odor Responses Following Olfactory Fear Conditioning in Awake Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- Persistent, generalized hypersensitivity of olfactory bulb interneurons after olfactory fear generalization.Neurobiology of learning and memory · 2017Article
- Amygdalar Gating of Early Sensory Processing through Interactions with Locus Coeruleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Associative learning and sensory neuroplasticity: how does it happen and what is it good for?Learning & memory (Cold Spring Harbor, N.Y.) · 2015Review
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1 author at 1 institution in 1 country.
Funding
Abstract
The anatomical organization of receptor neuron input into the olfactory bulb (OB) allows odor information to be transformed into an odorant-specific spatial map of mitral/tufted (M/T) cell glomerular activity at the upper level of the OB. In other sensory systems, neuronal representations of stimuli can be reorganized or enhanced following learning. While the mammalian OB has been shown to undergo experience-dependent plasticity at the glomerular level, it is still unclear if similar representational change occurs within (M/T) cell glomerular odor representations following learning. To address this, odorant-evoked glomerular activity patterns were imaged in mice expressing a GFP-based calcium indicator (GCaMP2) in OB (M/T) cells. Glomerular odor responses were imaged before and after olfactory associative conditioning to aversive foot shock. Following conditioning, we found no overall reorganization of the glomerular representation. Training, however, did significantly alter the amplitudes of individual glomeruli within the representation in mice in which the odor was presented together with foot shock. Further, the specific pairing of foot shock with odor presentations lead to increased responses primarily in initially weakly activated glomeruli. Overall, these results suggest that associative conditioning can enhance the initial representation of odors within the OB by enhancing responses to the learned odor in some glomeruli.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.